Antegrade radical retropubic prostatectomy with preliminary ligation of vascular pedicles in 614 consecutive patients.

Antegrade radical retropubic prostatectomy with preliminary ligation of vascular pedicles in 614 consecutive patients. Research Abstract Details 

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Antegrade radical retropubic prostatectomy with preliminary ligation of vascular pedicles in 614 consecutive patients. Abstract Text:

Satoru Kawakami,Iwao Fukui,Junji Yonese,Yuhei Okubo,Shinya Yamamoto,Tetsuro Tsukamoto,Yuichi Ishikawa,

BACKGROUND: We present our procedure of antegrade radical retropubic prostatectomy with preliminary ligation of vascular pedicles and assess the time trends of patient characteristics, surgical and oncological outcome in 614 consecutive patients in a single institution over a 12-year period. METHODS: From April 1994 to December 2005, 614 consecutive Japanese patients with cT1-3N0M0 prostate cancer underwent antegrade radical prostatectomy with preliminary ligation of vascular pedicles (dorsal vein complex and prostatic pedicles) prior to the tumor manipulation. Biochemical progression is defined as prostate-specific antigen value over 0.2 ng/ml or the initiation of therapy after surgery. Biochemical progression-free, cancer-specific and overall survival curves were calculated by the Kaplan-Meier method. RESULTS: During the study period pre-operative PSA, clinical T stage, duration of surgery, amount of estimated blood loss have decreased. Pathological stage showed a significant downward migration and the rate of positive surgical margin has also decreased. At a mean follow-up of 48 months, 21 men were dead including eight who died of prostate cancer. Overall and cancer-specific survival rates were 97/99% at 5 years and 89/95% at 10 years, respectively. Neoadjuvant hormonal treatment had no beneficial impact on oncological outcome of patients regardless of clinical stage. In 370 patients treated surgically alone, cancer-specific and biochemical progression-free survival rates were 99.6/80.5% at 5 years and 97.9/73.3% at 10 years for patients with clinical T1/2 disease and 95.5/41.9% at 5 years and 87.5/41.9% at 10 years for those with T3 disease, respectively. In the 370 patients biochemical progression-free survival has been significantly improved over the 12-year period (P < 0.0001). CONCLUSIONS: Antegrade radical prostatectomy with preliminary ligation of vascular pedicles can be performed with excellent oncological outcome.

Antegrade radical retropubic prostatectomy with preliminary ligation of vascular pedicles in 614 consecutive patients. Publishing Authors By Initials

S Kawakami,I Fukui,J Yonese,Y Okubo,S Yamamoto,T Tsukamoto,Y Ishikawa,

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Antegrade radical retropubic prostatectomy with preliminary ligation of vascular pedicles in 614 consecutive patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Japanese journal of clinical oncology

VOLUME: 37

Page Numbers: 528-33

Journal Abbreviation: Jpn. J. Clin. Oncol.

ISSN: 1465-3621

DAY: 27

MONTH: Jul

YEAR: 2007

Antegrade radical retropubic prostatectomy with preliminary ligation of vascular pedicles in 614 consecutive patients. Information

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LANGUAGE: eng

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AFFILIATION: Department of Urology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan. s-kawakami@tmd.ac.jp

Country: Japan

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MEDLINETA: Jpn J Clin Oncol

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