Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment.

Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Research Abstract Details 

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Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Abstract Text:

Angshuman Sarkar,Nishita Parikh,Stephen A Hearn,Margaret T Fuller,Salli I Tazuke,Cordula Schulz,Angshuman Sarkar,Nishita Parikh,Stephen A Hearn,Margaret T Fuller,Salli I Tazuke,Cordula Schulz,

The capacity of stem cells to self renew and the ability of stem cell daughters to differentiate into highly specialized cells depend on external cues provided by their cellular microenvironments [1-3]. However, how microenvironments are shaped is poorly understood. In testes of Drosophila melanogaster, germ cells are enclosed by somatic support cells. This physical interrelationship depends on signaling from germ cells to the Epidermal growth factor receptor (Egfr) on somatic support cells [4]. We show that germ cells signal via the Egf class ligand Spitz (Spi) and provide evidence that the Egfr associates with and acts through the guanine nucleotide exchange factor Vav to regulate activities of Rac1. Reducing activity of the Egfr, Vav, or Rac1 from somatic support cells enhanced the germ cell enclosure defects of a conditional spi allele. Conversely, reducing activity of Rho1 from somatic support cells suppressed the germ cell enclosure defects of the conditional spi allele. We propose that a differential in Rac and Rho activities across somatic support cells guides their growth around the germ cells. Our novel findings reveal how signals from one cell type regulate cell-shape changes in another to establish a critical partnership required for proper differentiation of a stem cell lineage.

Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Publishing Authors By Initials

A Sarkar,N Parikh,SA Hearn,MT Fuller,SI Tazuke,C Schulz,A Sarkar,N Parikh,SA Hearn,MT Fuller,SI Tazuke,C Schulz,

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Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current biology : CB

VOLUME: 17

Page Numbers: 1253-8

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 17

MONTH: Jul

YEAR: 2007

Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment.

AFFILIATION: Department of Molecular Biology and Microbiology, Case Western Reserve, University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

Country: England

AGENCY: United States NICHD

GRANT: U54 HD 31398

ACRONYM: HD

MEDLINETA: Curr Biol

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