Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation.

Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Research Abstract Details 

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Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Abstract Text:

A ,H Peters,R Balling,G R Martin,

Vertebrate organogenesis is initiated at sites that are often morphologically indistinguishable from the surrounding region. Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior to the first morphological manifestation of odontogenesis. We provide evidence that the sites of Pax9 expression in the mandibular arch are positioned by the combined activity of two signals, one (FGF8) that induces Pax9 expression and the other (BMP2 and BMP4) that prevents this induction. Thus it appears that the position of the teeth is determined by a combination of two different types of signaling molecules produced in wide but overlapping domains rather than by a single localized inducer. We suggest that a similar mechanism may be used for specifying the sites of development of other organs.

Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Publishing Authors By Initials

A ,H Peters,R Balling,GR Martin,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cell

VOLUME: 90

Page Numbers: 247-55

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 25

MONTH: Jul

YEAR: 1997

Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Information

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LANGUAGE: eng

NlmUniqueID: 413066

Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Information

Substance Name: Fibroblast Growth Factors

Registry Number: 62031-54-3

Grant and Affiliation Information for Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation.

AFFILIATION: Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco 94143-0452, USA.

Country: UNITED STATES

AGENCY: United States NICHD

GRANT: R01 HD34380

ACRONYM: HD

MEDLINETA: Cell

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