Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs.

Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs. Research Abstract Details 

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Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs. Abstract Text:

J C Winter,

It has been observed that agents with agonist activity at 5-HT(2A) receptors prevent neurotoxicity induced by the non-competitive NMDA antagonist, dizocilpine (MK-801). Subsequent behavioral studies reported complete antagonism by LSD and DOM of the stimulus effects of the related NMDA antagonist, phencyclidine [PCP]. The present study sought to extend those observations to include other psychoactive drugs. Male F-344 rats were trained in a 2-lever, fixed-ratio 10, food-reinforced task with PCP (3.0 mg/kg; IP; 30 min pretreatment) as a discriminative stimulus. Tests of generalization were then conducted using the training dose of PCP in combination with a range of doses of DOM, LSD, d-amphetamine, MDMA, psilocybin, buspirone, and GHB. All of the drugs tested in combination with PCP produced a statistically significant diminution of PCP-appropriate responding but for none was antagonism complete. These data, obtained using a stimulus control model of the hallucinogenic effects of PCP, fail to support the hypothesis that LSD and DOM completely antagonize stimulus control by PCP. Instead, the data suggest complex interactions between PCP-induced stimulus control and a variety of psychoactive drugs including GHB, an agent with no known affinity for serotonergic receptors.

Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs. Publishing Authors By Initials

JC Winter,

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Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 88

Page Numbers: 189-95

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 15

MONTH: 08

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, 102 Farber Hall, Buffalo, NY 14214-3000, USA.

Country: United States

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MEDLINETA: Pharmacol Biochem Behav

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