Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. Abstract Text:

Alan B Cantor,Hiromi Iwasaki,Yojiro Arinobu,Tyler B Moran,Hirokazu Shigematsu,Matthew R Sullivan,Koichi Akashi,Stuart H Orkin,

The zinc finger transcription factor GATA-1 requires direct physical interaction with the cofactor friend of GATA-1 (FOG-1) for its essential role in erythroid and megakaryocytic development. We show that in the mast cell lineage, GATA-1 functions completely independent of FOG proteins. Moreover, we demonstrate that FOG-1 antagonizes the fate choice of multipotential progenitor cells for the mast cell lineage, and that its down-regulation is a prerequisite for mast cell development. Remarkably, ectopic expression of FOG-1 in committed mast cell progenitors redirects them into the erythroid, megakaryocytic, and granulocytic lineages. These lineage switches correlate with transcriptional down-regulation of GATA-2, an essential mast cell GATA factor, via switching of GATA-1 for GATA-2 at a key enhancer element upstream of the GATA-2 gene. These findings illustrate combinatorial control of cell fate identity by a transcription factor and its cofactor, and highlight the role of transcriptional networks in lineage determination. They also provide evidence for lineage instability during early stages of hematopoietic lineage commitment.

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. Publishing Authors By Initials

AB Cantor,H Iwasaki,Y Arinobu,TB Moran,H Shigematsu,MR Sullivan,K Akashi,SH Orkin,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of experimental medicine

VOLUME: 205

Page Numbers: 611-24

Journal Abbreviation: J. Exp. Med.

ISSN: 1540-9538

DAY: 25

MONTH: 02

YEAR: 2008

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985109

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.

AFFILIATION: Division of Pediatric Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA. alan.cantor@childrens.harvard.edu

Country: United States

AGENCY: United States Howard Hugh

GRANT: R01 HL075705

ACRONYM: HL

MEDLINETA: J Exp Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage Related Publications

• Acquired lymphangioma (lymphangiectasis). Report of a case.
• An extended transcriptional network for pluripotency of embryonic stem cells.
• Animal models (spontaneous) for human disease. Experiments of nature.
• Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.
• CUTANEOUS FORM OF PERIARTERITIS NODOSA--AN ENTITY?
• Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.
• ETV6-NTRK3 Fusion Oncogene Initiates Breast Cancer from Committed Mammary Progenitors via Activation of AP1 Complex.
• Evaluation of the principles concerned in the management of trauma to the kidney.
• From the Cover: DNA polymorphisms at the BCL11A, HBS1L-MYB, and {beta}-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.
• Funding for Canadian health care research.
• Granulomatous perivasculitis in Crohn's disease.
• Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.
• METHEMOGLOBINEMIA ASSOCIATED WITH THE INGESTION OF DIASONE.
• MICROCIRCULATORY EFFECTS OF ANESTHESIA IN SHOCK.
• Mastocytosis in animals.
• Methemoglobinemia associated with the ingestion of Diasone.
• Molecular genetics of chronic granulomatous disease.
• Potential health risks of complementary alternative medicines in HIV patients.
• Rb and hematopoiesis: stem cells to anemia.
• Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.
• Site-directed, virus-free, and inducible RNAi in embryonic stem cells.
• Subspecialties in family medicine: a question of values.
• Symposium on skin diseases common to man and animal. Introductory comments.
• The increased pathogenicity of Bacillus lactis aerogenes in urinary tract infections.
• Today's scabies.
• [Prolapse of fibromyxoma of the urinary bladder through the urethra in a 1-year-old boy.]