Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling.

Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. Research Abstract Details 

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Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. Abstract Text:

Vascular remodelling is central to the pathophysiology of hypertension and atherosclerosis. Recent evidence suggests the pivotal role of vasoactive substances occurring in the blood vessel, such as angiotensin II (AII), in the control of vascular growth. We recently discovered that C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is produced by vascular endothelial cells and can act as an endothelium-derived relaxing peptide. We also demonstrated gene expression of CNP and the ANP-B receptor, which is one of the three subtypes of the natriuretic peptide receptor and is specific to CNP in blood vessels in vivo. Thus, we propose the existence of a "vascular natriuretic peptide system (NPS)" similar to the vascular renin-angiotensin system (RAS). The present study showed that CNP exerted a growth-inhibitory action and antagonised the growth-promoting action of AII, which was mediated through the AII subtype 1 receptor in cultured vascular smooth muscle cells. In neointimal lesions of rat carotid artery, CNP gene transcript was detectable 2 weeks after balloon injury, and ANP-B receptor gene expression was augmented. These findings suggest that the vascular NPS is activated in proliferative vascular lesions, suppressing further proliferation by antagonising the action of the vascular RAS.

Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. Publishing Authors By Initials

For similar chemical and pharmacologic phenomena: stimulation, chemical research abstracts see: chemical and pharmacologic phenomena: stimulation, chemical research

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Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood pressure. Supplement

VOLUME: 5

Page Numbers: 49-53

Journal Abbreviation:

ISSN: 0803-8023

DAY: 26

MONTH: 02

YEAR: 1994

Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9300787

Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. Keywords Mesh Terms:

KEYWORDS: Stimulation, Chemical

MESH TERMS: physiology

Chemical & Substance for Abstract: Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. Information

Substance Name: atrial natriuretic factor receptor C

Registry Number: EC 4.6.1.2

Grant and Affiliation Information for Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling.

AFFILIATION: Department of Medicine, Kyoto University School of Medicine, Japan.

Country: NORWAY

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MEDLINETA: Blood Press Suppl

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