Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm.

Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Research Abstract Details 

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Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Abstract Text:

Rick E Bernardi,K Matthew Lattal,S Paul Berger,

In experiments examining the potential reconsolidation of drug-associated contextual memories, rats were given a single pairing of cocaine with a specific context, and the ability of the protein synthesis inhibitor anisomycin administered following a context-only memory retrieval trial to impair conditioned locomotor sensitization was tested. Rats receiving 150 mg/kg anisomycin immediately following a 5-min reexposure to the cocaine-conditioned context showed decreased activity compared with the vehicle control group in response to a low-dose cocaine challenge during a subsequent test for conditioned sensitization. This effect was not seen when anisomycin was administered following a 30-min reexposure to the context or when anisomycin was administered 25 min after a 5-min reexposure. These results are consistent with a growing literature suggesting that following retrieval, associative contextual memories may undergo a transient protein synthesis-dependent reconsolidation phase that normally serves to maintain memory.

Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Publishing Authors By Initials

RE Bernardi,KM Lattal,SP Berger,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Behavioral neuroscience

VOLUME: 121

Page Numbers: 156-63

Journal Abbreviation: Behav. Neurosci.

ISSN: 0735-7044

DAY: 3

MONTH: Feb

YEAR: 2007

Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8302411

Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Information

Substance Name: Cocaine

Registry Number: 50-36-2

Grant and Affiliation Information for Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm.

AFFILIATION: Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA. bernardi@ohsu.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH074547

ACRONYM: MH

MEDLINETA: Behav Neurosci

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