[Anisodamine in prevention and treatment of sepsis of severely burned patients]

[Anisodamine in prevention and treatment of sepsis of severely burned patients] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Anisodamine in prevention and treatment of sepsis of severely burned patients] Abstract Text:

J Chai,H Yang,Z Sheng,Z Guo,L Diao,C Shen,F Li,X Jia,L Li,M Xu,L He,D Hao,Y Yu,

OBJECTIVE: To observe the preventive effect of anisodamine on possible sepsis of patients with major burns and the effect of anisodamine on patients with sepsis. METHODS: Forty-two patients with extensive burn admitted to our burn institute from April 1998 to November 1999 were divided randomly into two groups: treatment group (T group) and control group (C group). In the T group, all 20 patients received fluid resuscitation regimen with anisodamine, and in the C group, 22 patients received the regimen with no anisodamine. A tonometery catheter was positioned in the stomach, connecting with the automatic gas analysis machine (Datex-Engtrom Corporation, Dutch) for determining gastric intramucosal pH (pHi). The plasma concentrations of diamine oxidase (DAO) and endotoxin were measured. Correlation analysis between pHi, DAO and endotoxin were made respectively during early stage of postburn. All the parameters in 7 patients with sepsis before and after administration of anisodamine were compared with those in 6 patients with sepsis without use of anisodamine. RESULTS: The incidence of sepsis in the T group was lower (20.0%) than that in C group (40.9%). The gastric pHi value in the early period of postburn was significantly higher in the T group than in the C group (P < 0.05). Concurrently, the plasma concentrations of DAO and endotoxin were significantly lower in the T group than in the C group (P < 0.05 or 0.01). A significant negative correlation was seen between the gastric pHi and respective values of DAO, endotoxin (P < 0.05 or 0.01). There were a decrease in gastric pHi, and an increase in plasma DAO and endotoxin level in patients with septic episode; however all the parameters after administration of anisodamine were improved compared with those in septic patients without use of anisodamine. CONCLUSIONS: Intestinal ischemic injury plays an important role in provoking sepsis during early postburn period. Anisodamine is effective in restoring intestinal circulation both in the shock phase and after the development of sepsis.

[Anisodamine in prevention and treatment of sepsis of severely burned patients] Publishing Authors By Initials

J Chai,H Yang,Z Sheng,Z Guo,L Diao,C Shen,F Li,X Jia,L Li,M Xu,L He,D Hao,Y Yu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Anisodamine in prevention and treatment of sepsis of severely burned patients] Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery

VOLUME: 38

Page Numbers: 686-9

Journal Abbreviation: Zhonghua Wai Ke Za Zhi

ISSN: 0529-5815

DAY: 8

MONTH: Sep

YEAR: 2000

[Anisodamine in prevention and treatment of sepsis of severely burned patients] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 153611

[Anisodamine in prevention and treatment of sepsis of severely burned patients] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Anisodamine in prevention and treatment of sepsis of severely burned patients] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Anisodamine in prevention and treatment of sepsis of severely burned patients]

AFFILIATION: Burn Institute, 304th Hospital, People's Liberation Army, Beijing 100037, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Wai Ke Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Anisodamine in prevention and treatment of sepsis of severely burned patients Related Publications

• An overview of vagal airway receptors.
• Element mixing distribution and structure feature of fusion zone in laser welding between different alloys and pure titanium.
• Endothelial function and carotid artery wall thickening in patients with early essential hypertension.
• Genetic factors underlying prostate cancer.
• Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene.
• Na(+)/K(+) -ATPase as a marker for detecting pulmonary sensory receptors.
• RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest.
• The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.
• [A case of sepsis and multiple organ dysfunction syndrome complicated by Staphylococcus infection]
• [Anisodamine in prevention and treatment of sepsis of severely burned patients]
• [Association study on HLA-DP and -DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province]
• [Change of catecholamine in serum and hippocampus of rats after electromagnetic irradiation and the selection of protective site]
• [Changes of phosphorylation states of Cx43 protein in Chinese hamster lung cells induced by SiO2]
• [Double uterus and hydatidiform mole in the malformed uterus: report of one case]
• [Early diagnosis of pancreatic cancer is essential to improving the effect of treatment]
• [Effect of oxidated low-density lipoprotein on early apoptosis of vascular smooth muscle cell]
• [Extinguishment of harmful algae by organo-clay]
• [Humoral immune response in mice to hybrid nucleic acid vaccines containing Plasmodium falciparum merozoite surface protein 1 block 17-based gene]
• [PCR in detecting the correlation between infection of HBV and cholelithiasis]
• [Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer]
• [Primary extranodal lymphomas: analyses of clinical characteristics and misdiagnoses of 139 cases]
• [Relationship between Helicobacter pylori infection and expression of c-myc, Bcl-2, and Bax protein in different gastric mucosa lesions]
• [Researches in forensic biomechanics]
• [Study on antitumor effect and mechanism of aloe polysaccharides]
• [Study on the genic polymorphism of HLA-DRB1 in a population in the north of China]
• [The effect of radix Pseudostellariae from 8 habitats on spleen-deficiency and immunologic function]
• [The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells]
• [Treatment of burns combined injury]
• [Wavelet feature extraction and classification of Doppler ultrasound blood flow signals]
• [p15 gene expression in acute lymphoblastic leukemia cell line Molt4 induced by arsenic trioxide]