Angiotensinogen gene polymorphism as a risk factor for ischemic stroke.

Angiotensinogen gene polymorphism as a risk factor for ischemic stroke. Research Abstract Details 

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Angiotensinogen gene polymorphism as a risk factor for ischemic stroke. Abstract Text:

Taizen Nakase,Toshiki Mizuno,Sanae Harada,Kei Yamada,Tsunehiko Nishimura,Kotaro Ozasa,Yoshiyuki Watanabe,Ken Nagata,Taizen Nakase,Toshiki Mizuno,Sanae Harada,Kei Yamada,Tsunehiko Nishimura,Kotaro Ozasa,Yoshiyuki Watanabe,Ken Nagata,

While gene polymorphism for angiotensinogen (AGT) is reported to contribute to the regulation of blood pressure and salt sensitivity, its effect on the risk of ischemic stroke remains controversial. We hypothesized that polymorphism of the AGT gene could be a risk factor for ischemic stroke. Major clinical risk factors and the AGT gene M235T polymorphism were examined in 147 consecutive stroke patients and 133 healthy age-matched controls. All patients were categorized into four stroke types (single lacuna, multiple lacunae, large-artery atherosclerosis and branch atheromatous disease in brainstem) and two vascular groups (large and perforating arterial lesions). The AGT gene M allele significantly increased the risk of single lacuna, multiple lacunae and small arterial lesions, in male patients (p=0.029, 0.031 and 0.026, respectively). Synergistic effects of the AGT gene polymorphism and clinical risks were not observed. In conclusion, AGT M allele may present a risk of lacunar infarctions in Japanese men, independent of hypertension.

Angiotensinogen gene polymorphism as a risk factor for ischemic stroke. Publishing Authors By Initials

T Nakase,T Mizuno,S Harada,K Yamada,T Nishimura,K Ozasa,Y Watanabe,K Nagata,T Nakase,T Mizuno,S Harada,K Yamada,T Nishimura,K Ozasa,Y Watanabe,K Nagata,

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Angiotensinogen gene polymorphism as a risk factor for ischemic stroke. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical neuroscience : official journa

VOLUME: 14

Page Numbers: 943-7

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ISSN: 0967-5868

DAY: 3

MONTH: 08

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9433352

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Grant and Affiliation Information for Angiotensinogen gene polymorphism as a risk factor for ischemic stroke.

AFFILIATION: Department of Neurology, Research Institute for Brain and Blood Vessels, 6-10 Senshu Kubota Machi, Akita, Japan 010-0874. nakase@akita-noken.go.jp

Country: Scotland

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MEDLINETA: J Clin Neurosci

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