Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology.

Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Research Abstract Details 

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Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Abstract Text:

Sadaharu Higuchi,Haruhiko Ohtsu,Hiroyuki Suzuki,Heigoro Shirai,Gerald D Frank,Satoru Eguchi,

The intracellular signal transduction of AngII (angiotensin II) has been implicated in cardiovascular diseases, such as hypertension, atherosclerosis and restenosis after injury. AT(1) receptor (AngII type-1 receptor), a G-protein-coupled receptor, mediates most of the physiological and pathophysiological actions of AngII, and this receptor is predominantly expressed in cardiovascular cells, such as VSMCs (vascular smooth muscle cells). AngII activates various signalling molecules, including G-protein-derived second messengers, protein kinases and small G-proteins (Ras, Rho, Rac etc), through the AT(1) receptor leading to vascular remodelling. Growth factor receptors, such as EGFR (epidermal growth factor receptor), have been demonstrated to be 'trans'-activated by the AT(1) receptor in VSMCs to mediate growth and migration. Rho and its effector Rho-kinase/ROCK are also implicated in the pathological cellular actions of AngII in VSMCs. Less is known about the endothelial AngII signalling; however, recent studies suggest the endothelial AngII signalling positively, as well as negatively, regulates the NO (nitric oxide) signalling pathway and, thereby, modulates endothelial dysfunction. Moreover, selective AT(1)-receptor-interacting proteins have recently been identified that potentially regulate AngII signal transduction and their pathogenic functions in the target organs. In this review, we focus our discussion on the recent findings and concepts that suggest the existence of the above-mentioned novel signalling mechanisms whereby AngII mediates the formation of cardiovascular diseases.

Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Publishing Authors By Initials

S Higuchi,H Ohtsu,H Suzuki,H Shirai,GD Frank,S Eguchi,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical science (London, England : 1979)

VOLUME: 112

Page Numbers: 417-28

Journal Abbreviation: Clin. Sci.

ISSN: 1470-8736

DAY: 3

MONTH: Apr

YEAR: 2007

Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Information

Number of References: 123

LANGUAGE: eng

NlmUniqueID: 7905731

Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology.

AFFILIATION: Cardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL076770

ACRONYM: HL

MEDLINETA: Clin Sci (Lond)

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