Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle.

Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. Research Abstract Details 

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Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. Abstract Text:

Matthew C Petersen,Andrew S Greene,Matthew C Petersen,Andrew S Greene,

OBJECTIVE: The purpose of this study was to determine whether a high-salt diet modulates physiological angiogenesis in skeletal muscle by altering angiotensin II (ANGII) and vascular endothelial growth factor (VEGF) levels. METHODS: Sprague-Dawley rats were placed on a control diet (0.4% NaCl by weight) or high-salt diet (4.0% NaCl) prior to treatment with the vasodilator prazosin in the drinking water. In addition, a group of animals fed high salt were infused intravenously with ANGII at a low dose to prevent ANGII suppression by high salt, and a group of rats fed control diet were treated with the angiotensin II type I (AT(1)) receptor blocker losartan and prazosin. RESULTS: Prazosin induced significant angiogenesis in the tibialis anterior muscle after 1 week of treatment. High-salt-fed rats demonstrated a complete inhibition of this angiogenic response. Maintenance of ANGII levels restored prazosin-induced angiogenesis in animals fed a high-salt diet. In addition, losartan treatment blocked prazosin-induced angiogenesis in animals on a control diet. Western blot analysis indicated that prazosin-induced angiogenesis was independent of changes in muscle levels of VEGF. CONCLUSIONS: This study demonstrates an inhibitory effect of high salt intake on prazosin-induced angiogenesis. Further, these results indicate that ANGII acting through the AT(1) receptor is a critical pathway in this model of angiogenesis.

Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. Publishing Authors By Initials

MC Petersen,AS Greene,MC Petersen,AS Greene,

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Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Microcirculation (New York, N.Y. : 1994)

VOLUME: 14

Page Numbers: 583-91

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ISSN: 1073-9688

DAY: 21

MONTH: Aug

YEAR: 2007

Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. Information

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LANGUAGE: eng

NlmUniqueID: 9434935

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Grant and Affiliation Information for Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle.

AFFILIATION: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL29587

ACRONYM: HL

MEDLINETA: Microcirculation

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