Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development.

Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development. Abstract Text:

Hitoshi Yoshiji,Shigeki Kuriyama,Ryuichi Noguchi,Yasuhide Ikenaka,Mitsuteru Kitade,Kosuke Kaji,Junichi Yoshii,Koji Yanase,Masaharu Yamazaki,Kiyoshi Asada,Tatsuhiro Tsujimoto,Takemi Akahane,Masahito Uemura,Hiroshi Fukui,

Both angiotensin-II (AT-II) and vascular endothelial growth factor (VEGF) have been shown to play important roles in the progression of liver fibrosis. However, the interaction of AT-II with VEGF in the liver fibrosis has not been elucidated yet. The aim of the current study was to elucidate a possible association between these molecules, especially in conjunction with the hepatic stellate cells (HSC). The effect of AT-II type 1 receptor blocker (ARB) was assessed on several indices of choline-deficient l-amino acid-defined (CDAA)-induced liver fibrogenesis. This ARB significantly suppressed liver fibrosis development along with suppression of the VEGF expression and neovascularization in the liver. In the cultured activated HSC, AT-II induced VEGF in a dose- and time-dependent manner. ARB and LY333531, a protein kinase C (PKC) inhibitor, attenuated this augmentation. These results indicated that AT-II and VEGF interaction played an important role in liver fibrosis development, and that in the activated HSC, AT-II utilized type 1 receptor and PKC as an intracellular signaling pathway to induce VEGF.

Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development. Publishing Authors By Initials

H Yoshiji,S Kuriyama,R Noguchi,Y Ikenaka,M Kitade,K Kaji,J Yoshii,K Yanase,M Yamazaki,K Asada,T Tsujimoto,T Akahane,M Uemura,H Fukui,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 36

Page Numbers: 124-9

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 17

MONTH: 08

YEAR: 2006

Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9711801

Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development.

AFFILIATION: Third Department of Internal Medicine, Nara Medical University, Shijo-cho 840, Kashihara, Nara 634-8522, Japan.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hepatol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development Related Publications

• 2-Geranyl-1,4-naphthoquinone, a possible intermediate of anthraquinones in a Sesamum indicum hairy root culture.
• A numerical simulation of orthodontic tooth movement produced by a canine retraction spring.
• A numerical simulation of tooth movement produced by molar uprighting spring.
• A potent angiogenic factor, vascular endothelial growth factor, improves the survival of the on-going acute hepatic failure in rats.
• Angiotensin-II and vascular endothelial growth factor interaction plays an important role in rat liver fibrosis development.
• Aortic valve replacement in a patient with myelodysplastic syndrome and interstitial pneumonia.
• Blastocyst production by in vitro maturation and development of porcine oocytes in defined media following intracytoplasmic sperm injection.
• Construction and performance test of SGM-TRAIN at UVSOR.
• Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats.
• Diffusion-weighted imaging predicts postoperative persistence in meningioma patients with peritumoural abnormalities on magnetic resonance imaging.
• Direct comparison between transrectal and transperineal extended prostate biopsy for the detection of cancer.
• Effect of glucose levels during the in vitro culture in synthetic oviduct fluid medium on in vitro development of bovine oocytes matured and fertilized in vitro.
• Effects of quality and developmental stage on the survival of IVF-derived bovine blastocysts cultured in vitro after freezing and thawing.
• Eosinophilic cholecystitis as a rare manifestation of visceral larva migrans.
• Giant parapharyngeal space lipoma: case report and surgical approach.
• Ground based verification of JAXA hardware for life science experiments.
• Health locus of control and use of conventional and alternative care: a cohort study.
• Human D-amino acid oxidase: an update and review.
• Increased von Willebrand Factor Over Decreased ADAMTS13 Activity May Contribute to the Development of Liver Disturbance and Multiorgan Failure in Patients With Alcoholic Hepatitis.
• Muc4 is required for activation of ErbB2 in signet ring carcinoma cell lines.
• Multiple combined indirect procedure for the surgical treatment of children with moyamoya disease. A comparison with single indirect anastomosis and direct anastomosis.
• Neurodegenerative disorders in schizophrenia.
• Obstinate cough as a sole presenting symptom of non-metastatic renal cell carcinoma.
• Preoperative serum testosterone level as an independent predictor of treatment failure following radical prostatectomy.
• Renin-Angiotensin system inhibitors as therapeutic alternatives in the treatment of chronic liver diseases.
• Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor.
• Superior vena cava syndrome caused by supraclavicular lymph node metastasis of renal cell carcinoma.
• T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2.
• The HNF-1alpha-SNARE connection.
• [Prostate cancer]