Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension.

Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension. Research Abstract Details 

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Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension. Abstract Text:

C I Johnston,

There are now numerous angiotensin converting enzyme (ACE) inhibitors under development, clinical trial or in clinical use for cardiovascular disease, a situation analagous to the beta blockers. They currently vary in their chemical and physical structure, whether they contain a sulphydril group or are pro-drugs, and in their pharmacokinetics. Whether these differences will convey any special or particular clinical advantages to individual ACE inhibitors has yet to be established. Further research is necessary to determine whether tissue ACEs are merely isoenzymes or whether they differ in their functional properties. Different bioavailability in tissues of the individual ACE inhibitors could confer differing pharmacodynamic properties. ACE inhibitors have been a major advance in the treatment of hypertension and heart failure. In heart failure they have been shown to improve the haemodynamics, to improve symptoms, and most recently, to prolong survival. In hypertension, ACE inhibitors have some physiological advantages over current antihypertensive agents. They have several favourable cardiovascular effects without metabolic disadvantages which provide a theoretical basis for cardio-protection in hypertensive patients.

Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension. Publishing Authors By Initials

CI Johnston,

For similar male urogenital diseases: urologic diseases: kidney diseases research abstracts see: male urogenital diseases: urologic diseases: kidney diseases research

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Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 11

Page Numbers: 1097-115

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1989

Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension. Information

Number of References: 45

LANGUAGE: eng

NlmUniqueID: 8207790

Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension. Keywords Mesh Terms:

KEYWORDS: Kidney Diseases

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension. Information

Substance Name: Angiotensin-Converting Enzyme Inhibitors

Registry Number: 0

Grant and Affiliation Information for Angiotensin converting enzyme inhibitors: differences and advantages for first line therapy in hypertension.

AFFILIATION: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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