Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils.

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Abstract Text:

Aquilla S Turk,Christopher M Luty,Victoria Carr-Brendel,Igor Polyakov,Dan Consigny,Julie Grinde,Rajat Mukherjee,Charles M Strother,

INTRODUCTION: It is claimed that bioactive coils induce accelerated and more durable aneurysm healing. Data supporting this claim are quite limited. Our purpose was to compare the angiographic and histological results obtained following treatment with different coil types. METHODS: Bifurcation type aneurysms were surgically created in 24 dogs and treated using standard clinical techniques. Eight were treated with Guglielmi detachable coils (GDC), eight with first-generation Matrix coils, and eight with a combination of GDC and Matrix coils. The aneurysms were explanted and final angiographic evaluations performed 12 weeks after treatment. Angiographic and histological outcomes were documented. RESULTS: Increased coil compaction with aneurysm recurrence was found in aneurysms treated with first-generation Matrix coils as compared to standard GDC (P = 0.0001). In aneurysms treated with first-generation Matrix coils thrombus organization was better than in those treated with either standard GDC coils (P = 0.008) or with a combination of GDC and Matrix coils (P = 0.04). In aneurysms treated with first-generation Matrix coils there were no endothelialized vascular clefts within the coil mass, but they were seen in the majority of aneurysms treated with GDC or a combination of GDC and Matrix coils (P = 0.003). CONCLUSION: Aneurysms treated with first-generation Matrix coils showed the greatest degree of coil compaction and aneurysm recurrence on the final angiographic evaluation. Aneurysms treated with first-generation Matrix coils showed enhanced thrombus organization and absence of vascular clefts at the aneurysm neck that were markedly different from those treated with bare platinum coils or a combination of GDC and Matrix coils.

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Publishing Authors By Initials

AS Turk,CM Luty,V Carr-Brendel,I Polyakov,D Consigny,J Grinde,R Mukherjee,CM Strother,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroradiology

VOLUME: 50

Page Numbers: 57-65

Journal Abbreviation:

ISSN: 0028-3940

DAY: 27

MONTH: 09

YEAR: 2007

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1302751

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils.

AFFILIATION: Department of Radiology, University of Wisconsin Hospital and Clinics, Madison, WI, USA.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neuroradiology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils Related Publications

• A technique for improved quantitative characterization of intracranial aneurysms.
• Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils.
• Anomalous origin of the posterior inferior cerebellar artery from the internal carotid artery.
• Atypical teratoid rhabdoid tumors of childhood: diagnosis, treatment and challenges.
• Bayesian kernel methods for analysis of functional neuroimages.
• CT angiographic appearance of in-stent restenosis of intracranial arteries treated with the Wingspan stent.
• Comparison of platinum and first-generation Matrix coils in under-packed canine side-wall aneurysms: evaluation of progressive thrombosis.
• Continued progress in the evolution of endovascular therapy.
• Does reduction in vascular trauma during treatment of acutely ruptured saccular aneurysms reduce the incidence of vasospasm?
• Effect of Guglielmi detachable coil placement on intraaneurysmal pressure: experimental study in canines.
• Effect of Guglielmi detachable coils on intraaneurysmal flow: experimental study in canines.
• Effect of carotid artery stenting on cognitive function in patients with carotid artery stenosis: preliminary results.
• Effect of spatial alignment transformations in PCA and ICA of functional neuroimages.
• Endovascular treatment of high-flow carotid cavernous fistulas by stent-assisted coil placement.
• Hemodynamic versus hydrodynamic effects of Guglielmi detachable coils on intra-aneurysmal pressure and flow at varying pulse rate and systemic pressure.
• Highlights of the 30th Annual Meeting of the American Society of Neuroradiology.
• Intra-arterial thrombolysis for the treatment of patients with acute ischemic stroke.
• Intraoperative sonographic assessment of graft patency during extracranial-intracranial bypass.
• Measuring intraaneurysmal flow: risk of perforation.
• Osmotic disruption of the blood-ocular barriers.
• Practical tradeoffs between noise, quantitation, and number of iterations for maximum likelihood-based reconstructions.
• Spontaneous thrombosis of a traumatic posterior cerebral artery aneurysm in a child.
• The role of muscle action in interpretative reading.
• Thirty-ninth annual meeting of the American Society of Neuroradiology.
• Thirty-seventh annual meeting of the American Society of Neuroradiology.
• Training, experience, and evidence matter.
• Transcranial Doppler sonography: adding to the toolbox.
• Treatment of carotid artery aneurysms with platinum coils: an experimental study in dogs.
• Utility of CT angiography and MR angiography for the follow-up of experimental aneurysms treated with stents or Guglielmi detachable coils.
• Wall Shear Stress Variations in Basilar Tip Aneurysms investigated with Computational Fluid Dynamics.