Angiogenic inhibition reduces germinal matrix hemorrhage.

Angiogenic inhibition reduces germinal matrix hemorrhage. Research Abstract Details 

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Angiogenic inhibition reduces germinal matrix hemorrhage. Abstract Text:

Praveen Ballabh,Hongmin Xu,Furong Hu,Alex Braun,Kira Smith,Aracelie Rivera,Nanhong Lou,Zoltan Ungvari,Steven A Goldman,Anna Csiszar,Maiken Nedergaard,

The germinal matrix of premature infants is selectively vulnerable to hemorrhage within the first 48 h of life. To assess the role of vascular immaturity in germinal matrix hemorrhage (GMH), we evaluated germinal matrix angiogenesis in human fetuses and premature infants, as well as in premature rabbit pups, and noted active vessel remodeling in all three. Vascular endothelial growth factor (VEGF), angiopoietin-2 and endothelial cell proliferation were present at consistently higher levels in the germinal matrix relative to the white matter anlagen and cortical mantle. On that basis, we asked whether prenatal treatment with either of two angiogenic inhibitors, the COX-2 inhibitor celecoxib, or the VEGFR2 inhibitor ZD6474, could suppress the incidence of GMH in premature rabbit pups. Celecoxib treatment decreased angiopoietin-2 and VEGF levels as well as germinal matrix endothelial proliferation. Furthermore, treatment with celecoxib or ZD6474 substantially decreased the incidence of GMH. Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants.

Angiogenic inhibition reduces germinal matrix hemorrhage. Publishing Authors By Initials

P Ballabh,H Xu,F Hu,A Braun,K Smith,A Rivera,N Lou,Z Ungvari,SA Goldman,A Csiszar,M Nedergaard,

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Angiogenic inhibition reduces germinal matrix hemorrhage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature medicine

VOLUME: 13

Page Numbers: 477-85

Journal Abbreviation:

ISSN: 1078-8956

DAY: 1

MONTH: 04

YEAR: 2007

Angiogenic inhibition reduces germinal matrix hemorrhage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502015

Angiogenic inhibition reduces germinal matrix hemorrhage. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor Recep

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Angiogenic inhibition reduces germinal matrix hemorrhage. Information

Substance Name: Vascular Endothelial Growth Factor Recep

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Angiogenic inhibition reduces germinal matrix hemorrhage.

AFFILIATION: Department of Pediatrics, New York Medical College-Westchester Medical Center, Valhalla, New York 10595, USA. pballabh@msn.com

Country: United States

AGENCY: United States NINDS

GRANT: R01NS29813

ACRONYM: NS

MEDLINETA: Nat Med

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