Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report.

Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report. Research Abstract Details 

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Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report. Abstract Text:

M Majores,P Niehusmann,M von Lehe,I Blümcke,H Urbach,M Majores,P Niehusmann,M von Lehe,I Blümcke,H Urbach,

CASE REPORT: We report on a 46-year-old male patient with pharmacoresistant temporal lobe epilepsy (TLE). Based on ictal EEG patterns and MRI scans, Ammon's horn sclerosis (AHS) or an epilepsy-associated tumor was included in the differential diagnosis. RESULTS: Histopathological examination of the surgical specimen revealed the unusual finding of a monomorphous angiocentric neuroepithelial tumor composed of small round cells and bipolar processes with perivascular aggregation. Immunohistochemistry detected perivascular-oriented expression of GFAP and cytoplasmic immunoreactivity of EMA and vimentin. Mitotic or other signs of proliferative activity were lacking. During a 2-year follow-up, the patient was seizure-free. CONCLUSIONS: Albeit AHS is the most frequent finding in TLE specimens, uncommon neuroepithelial tumors with hippocampal growth pattern have to be considered in the differential diagnosis of mesial TLE. The present case meets the criteria of an angiocentric neuroepithelial tumor recently proposed as a new clinicopathological entity. These tumors may be compatible with a maldevelopmental origin during early brain development.

Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report. Publishing Authors By Initials

M Majores,P Niehusmann,M von Lehe,I Blümcke,H Urbach,M Majores,P Niehusmann,M von Lehe,I Blümcke,H Urbach,

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PUBMED ID PMID:

MEDLINE DATE: 2007 Nov-Dec

Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical neuropathology

VOLUME: 26

Page Numbers: 311-6

Journal Abbreviation: Clin. Neuropathol.

ISSN: 0722-5091

DAY: 31

MONTH: 01

YEAR: 2008

Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report. Information

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LANGUAGE: eng

NlmUniqueID: 8214420

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Grant and Affiliation Information for Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report.

AFFILIATION: Department of Neuropathology, University of Bonn Medical Center, Germany. majores@uni-bonn.de

Country: Germany

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MEDLINETA: Clin Neuropathol

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