Angelica sinensis: A Novel Adjunct to Prevent Doxorubicin-Induced Chronic Cardiotoxicity.

Angelica sinensis: A Novel Adjunct to Prevent Doxorubicin-Induced Chronic Cardiotoxicity. Research Abstract Details 

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Angelica sinensis: A Novel Adjunct to Prevent Doxorubicin-Induced Chronic Cardiotoxicity. Abstract Text:

Yan-Fei Xin,Guo-Liang Zhou,Min Shen,Yun-Xiang Chen,Shu-Peng Liu,Guo-Chan Chen,Hao Chen,Zhen-Qiang You,Yao-Xian Xuan,Yan-Fei Xin,Guo-Liang Zhou,Min Shen,Yun-Xiang Chen,Shu-Peng Liu,Guo-Chan Chen,Hao Chen,Zhen-Qiang You,Yao-Xian Xuan,Yan-Fei Xin,Guo-Liang Zhou,Min Shen,Yun-Xiang Chen,Shu-Peng Liu,Guo-Chan Chen,Hao Chen,Zhen-Qiang You,Yao-Xian Xuan,

Doxorubicin is an anthracycline antibiotic agent used in the treatment of a variety of solid and haematopoietic tumours, but its use is limited by formation of metabolites that induce acute and chronic cardiac toxicities. Angelica sinensis has been widely used to treat cardiovascular and cerebrovascular diseases in China. In the present study, we used an in vivo mouse model to explore whether A. sinensis could protect against doxorubicin-induced chronic cardiotoxicity. Male ICR mice were treated with distilled water or water extraction of A. sinensis (15 g/kg, orally) daily for 4 weeks, followed by saline or doxorubicin (15 mg/kg, intravenously) treatments weekly. Cardiotoxicity was assessed by electrocardiograph, antioxidant activity in cardiac tissues, serum levels of creatine kinase, aspartate aminotransferase (AST) and histopathological change in cardiac tissues. A cumulative dose of doxorubicin (60 mg/kg) caused animal death and myocardial injury characterized by increased QT interval and decreased heart rate in electrocardiograph, decrease of heart antioxidant activity, increase of serum AST, as well as myocardial lesions. Pre-treatment with A. sinensis significantly reduced mortality and improved heart performance of the doxorubicin-treated mice as evidenced from normalization of antioxidative activity and serum AST, preventing loss of myofibrils as well as improving arrhythmias and conduction abnormalities. Furthermore, the in vitro cytotoxic study showed that A. sinensis did not compromise the antitumour activity of doxorubicin. These results suggested that A. sinensis elicited a typical cardioprotective effect on doxorubicin-related oxidative stress, and could be a novel adjunct in the combination with doxorubicin chemotherapy.

Angelica sinensis: A Novel Adjunct to Prevent Doxorubicin-Induced Chronic Cardiotoxicity. Publishing Authors By Initials

YF Xin,GL Zhou,M Shen,YX Chen,SP Liu,GC Chen,H Chen,ZQ You,YX Xuan,YF Xin,GL Zhou,M Shen,YX Chen,SP Liu,GC Chen,H Chen,ZQ You,YX Xuan,YF Xin,GL Zhou,M Shen,YX Chen,SP Liu,GC Chen,H Chen,ZQ You,YX Xuan,

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Angelica sinensis: A Novel Adjunct to Prevent Doxorubicin-Induced Chronic Cardiotoxicity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Basic & clinical pharmacology & toxicology

VOLUME: 101

Page Numbers: 421-6

Journal Abbreviation: Basic Clin. Pharmacol. Toxicol

ISSN: 1742-7835

DAY: 25

MONTH: 10

YEAR: 2007

Angelica sinensis: A Novel Adjunct to Prevent Doxorubicin-Induced Chronic Cardiotoxicity. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Angelica sinensis: A Novel Adjunct to Prevent Doxorubicin-Induced Chronic Cardiotoxicity.

AFFILIATION: State Key Laboratory of Safety Evaluation for New Drugs, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.

Country: Denmark

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MEDLINETA: Basic Clin Pharmacol Toxicol

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