Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes.

Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. Research Abstract Details 

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Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. Abstract Text:

Yen-Hua Huang,Tzong-Huei Lee,Kuei-Jung Chan,Feng-Lin Hsu,Yu-Chih Wu,Mei-Hsien Lee,Yen-Hua Huang,Tzong-Huei Lee,Kuei-Jung Chan,Feng-Lin Hsu,Yu-Chih Wu,Mei-Hsien Lee,

BACKGROUND: Melanin is the pigment responsible for skin color. Melanin synthesis occurs with the participation of the tyrosinase (TYR) family of proteins including TYR, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2(TRP2/DCT). OBJECTIVE: The effect of a newly isolated natural compound that inhibits hyperpigmentation on the regulation of the TYR family of proteins was examined. METHODS: The natural compound, anemonin, was isolated from Clematis crassifolia Benth and was used to inhibit cellular TYR activity; it was found to have a low cytotoxicity (cell viability > 80%) in human melanocytes. RESULTS: In human melanocytes, anemonin showed both time- and dose-dependent inhibition (IC(50) 43.5muM) of TYR. Western blot analysis and immunocytochemical staining revealed that expression of TYR, TRP1, and TRP2 was decreased in anemonin-treated melanocytes. Additionally, reverse transcription and quantitative real-time polymerase chain reaction analyses revealed that expression of mRNAs for MITF, TYR, TYRP1, and TYRP2 was also suppressed by anemonin. CONCLUSION: The natural compound, anemonin, an active compound of C. crassifolia, inhibits pigmentation synthesis in human melanocytes. Anemonin inhibits melanin synthesis by inhibiting the transcription of the genes encoding MITF, TYR, TRP1, and TRP2. This natural compound may be a candidate for cosmetic use.

Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. Publishing Authors By Initials

YH Huang,TH Lee,KJ Chan,FL Hsu,YC Wu,MH Lee,YH Huang,TH Lee,KJ Chan,FL Hsu,YC Wu,MH Lee,

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Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of dermatological science

VOLUME: 49

Page Numbers: 115-23

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ISSN: 0923-1811

DAY: 4

MONTH: 09

YEAR: 2007

Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes.

AFFILIATION: Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Country: Netherlands

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MEDLINETA: J Dermatol Sci

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