Androstene-3,5-dienes as ER-beta selective SERMs.

Androstene-3,5-dienes as ER-beta selective SERMs. Research Abstract Details 

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Androstene-3,5-dienes as ER-beta selective SERMs. Abstract Text:

Timothy A Blizzard,Candido Gude,Jerry D Morgan,Wanda Chan,Elizabeth T Birzin,Marina Mojena,Consuelo Tudela,Fang Chen,Kristin Knecht,Qin Su,Bryan Kraker,Ralph T Mosley,Mark A Holmes,Susan P Rohrer,Milton L Hammond,

A series of androstene-3,5-diene derivatives were prepared. Despite lacking the C-3 hydroxyl previously believed necessary for ER activity, some of the analogs retained surprising affinity for ER-beta. For example, diene 4 retained excellent selectivity and potency as an ER-beta agonist and was more selective for ER-beta over the androgen receptor (AR).

Androstene-3,5-dienes as ER-beta selective SERMs. Publishing Authors By Initials

TA Blizzard,C Gude,JD Morgan,W Chan,ET Birzin,M Mojena,C Tudela,F Chen,K Knecht,Q Su,B Kraker,RT Mosley,MA Holmes,SP Rohrer,ML Hammond,

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Androstene-3,5-dienes as ER-beta selective SERMs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6295-8

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 7

MONTH: 09

YEAR: 2007

Androstene-3,5-dienes as ER-beta selective SERMs. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Androstene-3,5-dienes as ER-beta selective SERMs.

AFFILIATION: Merck Research Laboratories, Rahway, NJ 07065, USA. tim_blizzard@merck.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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