Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus.

Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Abstract Text:

Erich N Ottem,Laurel A Beck,Cynthia L Jordan,S Marc Breedlove,

Castration of adult male rats causes the dendrites of androgen-sensitive motoneurons of the spinal nucleus of the bulbocavernosus (SNB) to retract. Brain-derived neurotrophic factor (BDNF), via activation of tyrosine receptor kinase B (trkB), has been implicated in mediating androgen effects on SNB dendrites. We used in situ hybridization to demonstrate that SNB motoneurons in gonadally intact adult male rats contain mRNA for both BDNF and trkB. Two weeks after gonadectomy, both transcripts were significantly decreased in SNB motoneurons but not in the non-androgen-responsive motoneurons of the adjacent retrodorsolateral nucleus (RDLN). In a second experiment, target perineal and foot muscles of SNB and RDLN motoneurons, respectively, were injected with the retrograde tracer Fluorogold, and then immunocytochemistry was performed to examine the distribution of BDNF and trkB proteins in SNB and RDLN motoneurons and their glutamatergic afferents. Confocal analysis revealed that gonadectomy induces a loss of BDNF protein in SNB dendrites but not in RDLN dendrites. Testosterone treatment of castrates prevented the loss of BDNF from SNB dendrites. Confocal analysis also revealed trkB protein in SNB and RDLN dendrites and in their glutamatergic afferents. Gonadectomy had no discernable effect on trkB protein in SNB or RDLN motoneurons or in their glutamatergic afferents. These results suggest that androgen maintains a BDNF-signaling pathway in SNB motoneurons that may underlie the maintenance of dendritic structure and synaptic signaling.

Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Publishing Authors By Initials

EN Ottem,LA Beck,CL Jordan,SM Breedlove,

For similar organic chemicals: amidines: stilbamidines research abstracts see: organic chemicals: amidines: stilbamidines research

PUBMED ID PMID:

MEDLINE DATE:

Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Endocrinology

VOLUME: 148

Page Numbers: 3655-65

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 26

MONTH: 04

YEAR: 2007

Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Keywords Mesh Terms:

KEYWORDS: Stilbamidines

MESH TERMS: physiology

Chemical & Substance for Abstract: Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Information

Substance Name: Receptor, trkB

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus.

AFFILIATION: Neuroscience Program, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824, USA. ottem@msu.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS28421

ACRONYM: NS

MEDLINETA: Endocrinology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus Related Publications

• Androgen receptors are required for full masculinization of the ventromedial hypothalamus (VMH) in rats.
• Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus.
• Fraternizing with gender differences.
• Gonadal steroids regulate neural plasticity in the sexually dimorphic nucleus of the preoptic area of adult male and female rats.
• Hand Asymmetry in Heterosexual and Homosexual Men and Women: Relationship to 2D:4D Digit Ratios and Other Sexually Dimorphic Anatomical Traits.
• Perceptions of social support from pregnant and parenting teens using community-based doulas.
• Pubertal growth of the medial amygdala delayed by short photoperiods in the Siberian hamster, Phodopus sungorus.
• Sexual dimorphism and steroid responsiveness of the posterodorsal medial amygdala in adult mice.
• Sexual dimorphism in neuronal number of the posterodorsal medial amygdala is independent of circulating androgens and regional volume in adult rats.
• Spatial Ability and Prenatal Androgens: Meta-Analyses of Congenital Adrenal Hyperplasia and Digit Ratio (2D:4D) Studies.
• The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation.