ANCA associated pauci-immune retinal vasculitis.

ANCA associated pauci-immune retinal vasculitis. Research Abstract Details 

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ANCA associated pauci-immune retinal vasculitis. Abstract Text:

BACKGROUND: Antinuclear cytoplasmic antibodies (ANCA) are useful diagnostic serological markers for the most common forms of necrotising vasculitis. ANCA associated vasculitides represent distinctive clinicopathological categories--for example, Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, and idiopathic necrotising crescentic glomerulonephritis, collectively known as the small vessel pauci-immune vasculitides. METHOD: Three cases of ANCA associated pauci-immune retinal vasculitis are described. Their systemic features are described and the clinical significance of ANCA as a diagnostic test in relation to retinal vasculitis discussed. RESULTS: These three cases represent a spectrum of clinical features associated with retinal vasculitis. Two cases have evolved into clinical recognisable entities as microscopic polyangiitis. Adherence to the international consensus statement on testing and reporting of ANCA is recommended and the authors speculate that the incidence of microscopic polyangiitis may be underestimated because of the under-recognition of systemic involvement in patients with retinal vasculitis. CONCLUSION: The receipt of a positive ANCA result should always raise the suspicion of a pauci-immune systemic vasculitis and prompt appropriate investigation. The authors emphasise the importance of the evaluation of systemic features in these patients with retinal vasculitis, enabling earlier recognition and thereby preventing significant morbidity and mortality.

ANCA associated pauci-immune retinal vasculitis. Publishing Authors By Initials

For similar cardiovascular diseases: vascular diseases: vasculitis research abstracts see: cardiovascular diseases: vascular diseases: vasculitis research

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ANCA associated pauci-immune retinal vasculitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 89

Page Numbers: 608-11

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: May

YEAR: 2005

ANCA associated pauci-immune retinal vasculitis. Information

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LANGUAGE: eng

NlmUniqueID: 421041

ANCA associated pauci-immune retinal vasculitis. Keywords Mesh Terms:

KEYWORDS: Vasculitis

MESH TERMS: diagnosis

Chemical & Substance for Abstract: ANCA associated pauci-immune retinal vasculitis. Information

Substance Name: Biological Markers

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Grant and Affiliation Information for ANCA associated pauci-immune retinal vasculitis.

AFFILIATION: Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow G12 9TA, UK. mjgallagher@doctors.org.uk

Country: England

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MEDLINETA: Br J Ophthalmol

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