Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells.

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Abstract Text:

Chen-Feng Qi,Jeff X Zhou,Chang Hoon Lee,Zohreh Naghashfar,Shao Xiang,Alexander L Kovalchuk,Torgny N Fredrickson,Janet W Hartley,Derry C Roopenian,Wendy F Davidson,Siegfried Janz,Herbert C Morse,

We have compared histologic features and gene expression profiles of newly identified plasmacytomas from NFS.V(+) congenic mice with plasmacytomas of IL6 transgenic, Fasl mutant, and SJL-beta2M(-/-) mice. NFS.V(+) tumors comprised an overlapping morphologic spectrum of high-grade/anaplastic, intermediate-grade/plasmablastic, and low-grade/plasmacytic cases with similarities to subsets of human multiple myeloma and plasmacytoma. Microarray and immunohistochemical analyses of genes expressed by the most prevalent tumors, plasmablastic plasmacytomas, showed them to be most closely related to immunoblastic lymphomas, less so to plasmacytomas of Fasl mutant and SJL mice, and least to plasmacytic plasmacytomas of IL6 transgenic mice. Plasmablastic tumors seemed to develop in an inflammatory environment associated with gene signatures of T cells, natural killer cells, and macrophages not seen with plasmacytic plasmacytomas. Plasmablastic plasmacytomas from NFS.V(+) and SJL-beta2M(-/-) mice did not have structural alterations in Myc or T(12;15) translocations and did not express Myc at high levels, regular features of transgenic and pristane-induced plasmacytomas. These findings imply that, as for human multiple myeloma, Myc-independent routes of transformation contribute to the pathogenesis of these tumors. These findings suggest that plasma cell neoplasms of mice and humans exhibit similar degrees of complexity. Mouse plasmacytomas, previously considered to be homogeneous, may thus be as diverse as their human counterparts with respect to oncogenic mechanisms of plasma cell transformation. Selecting specific types of mouse plasmacytomas that relate most closely to subtypes of human multiple myeloma may provide new opportunities for preclinical testing of drugs for treatment of the human disease.

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Publishing Authors By Initials

CF Qi,JX Zhou,CH Lee,Z Naghashfar,S Xiang,AL Kovalchuk,TN Fredrickson,JW Hartley,DC Roopenian,WF Davidson,S Janz,HC Morse,

For similar neoplasms: neoplasms by histologic type: neoplasms, plasma cell: plasmacytoma research abstracts see: neoplasms: neoplasms by histologic type: neoplasms, plasma cell: plasmacytoma research

PUBMED ID PMID:

MEDLINE DATE:

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 2439-47

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Mar

YEAR: 2007

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Keywords Mesh Terms:

KEYWORDS: Plasmacytoma

MESH TERMS: pathology

Chemical & Substance for Abstract: Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Information

Substance Name: Interleukin-6

Registry Number: 0

Grant and Affiliation Information for Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells.

AFFILIATION: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Cancer Institute, NIH, Rockville, Maryland 20852, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK56597

ACRONYM: DK

MEDLINETA: Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells Related Publications

• A dinoflagellate AAA family member rescues a conditional yeast G1/S phase cyclin mutant through increased CLB5 accumulation.
• Advances in pharmacogenomics of antiretrovirals: an update.
• Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells.
• Assessing the impact of substance use and hepatitis coinfection on atazanavir and lopinavir trough concentrations in HIV-infected patients during therapeutic drug monitoring.
• Bone morphogenetic protein receptor 2 mutations in pulmonary hypertension.
• Buprenorphine assay and plasma concentration monitoring in HIV-infected substance users.
• Compartmental pharmacokinetic analysis of oral amprenavir with secondary peaks.
• Determination of lopinavir cerebral spinal fluid and plasma ultrafiltrate concentrations by liquid chromatography coupled to tandem mass spectrometry.
• Direct selection of RNA beacon aptamers.
• Drug interactions between proton pump inhibitors and antiretroviral drugs.
• Duplicate publication.
• Effects of pyriproxyfen on California red scale (Hemiptera: Diaspididae) development and reproduction.
• Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation.
• Genome-wide analysis of transcriptional dependence and probable target sites for Abf1 and Rap1 in Saccharomyces cerevisiae.
• Global infectious disease surveillance and health intelligence.
• Global preparedness for public health emergencies.
• HIV pharmacotherapy issues, challenges, and priorities in sub-Saharan African countries.
• Hierarchical assembly of the siliceous skeletal lattice of the hexactinellid sponge Euplectella aspergillum.
• High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation.
• Integration of atazanavir into an existing liquid chromatography UV method for protease inhibitors: validation and application.
• Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV.
• Pandemic influenza: studying the lessons of history.
• Rotationally resolved spectroscopy of jet-cooled NbMo.
• Simulations of dynamics and viscoelasticity in highly entangled solutions of semiflexible rods.
• Technology evaluation: BLP-25, Biomira Inc.
• The US pandemic influenza implementation plan at six months.
• Toxicity of systemic neonicotinoid insecticides to avocado thrips in nursery avocado trees.
• Transcription factor access to promoter elements.
• Use of the finite element method to assess impact of current on forearm and wrist during an electrical accident.
• Wide dynamic range germanium detector for perturbation crystallography.