Anaphylactic shock induced by gadoterate meglumine (DOTAREM).

Anaphylactic shock induced by gadoterate meglumine (DOTAREM). Research Abstract Details 

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Anaphylactic shock induced by gadoterate meglumine (DOTAREM). Abstract Text:

The use of contrast agent for magnetic resonance imaging improves the effectiveness of this diagnostic examination. Complexes of godolinium, which appear to be well tolerated, are used for this purpose. A few cases of anaphylactic shock have been attributed to these agents. We report a case of anaphylactic shock due to gadoterate meglumine (DOTAREM). While undergoing a magnetic resonance imaging examination, a 33-year-old nonatopic female patient became severely hypotensive, lost consciousness, and had generalized erythema immediately after the intravenous injection of this product. She recovered rapidly after she was given injection of epinephrine and her blood volume was restored with intravenous fluids. That DOTAREM had caused this immediate hypersensitivity reaction was proven by the positivity of prick-test and intradermal test at 10-3 (0.37 mg/ml) and in vitro leukocyte histamine release test. The results of these tests indicated that it was the gadoteric acid rather than the meglumine component of DOTAREM that was responsible: positivity of IDR at 10 mg/ml. Skin tests and leukocyte histamine release test to gadopentetate dimeglumine (MAGNEVIST) were negative. In addition of the exceptional character, this observation provides evidence for an immediate hypersensitivity without cross reactivity with gadopentetate dimeglumine.

Anaphylactic shock induced by gadoterate meglumine (DOTAREM). Publishing Authors By Initials

For similar organic chemicals: organometallic compounds research abstracts see: organic chemicals: organometallic compounds research

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Anaphylactic shock induced by gadoterate meglumine (DOTAREM). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European annals of allergy and clinical immunology

VOLUME: 35

Page Numbers: 382-5

Journal Abbreviation:

ISSN: 1764-1489

DAY: 26

MONTH: Dec

YEAR: 2003

Anaphylactic shock induced by gadoterate meglumine (DOTAREM). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101466614

Anaphylactic shock induced by gadoterate meglumine (DOTAREM). Keywords Mesh Terms:

KEYWORDS: Organometallic Compounds

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Anaphylactic shock induced by gadoterate meglumine (DOTAREM). Information

Substance Name: gadolinium 1,4,7,10-tetraazacyclododecan

Registry Number: 92923-44-9

Grant and Affiliation Information for Anaphylactic shock induced by gadoterate meglumine (DOTAREM).

AFFILIATION: Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Hôpital Central, 54035 Nancy, France.

Country: France

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MEDLINETA: Eur Ann Allergy Clin Immunol

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