Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. Research Abstract Details 

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Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. Abstract Text:

Toby K Eisenstein,Joseph J Meissler,Qiana Wilson,John P Gaughan,Martin W Adler,

This study shows that two cannabinoids, Delta(9)-tetrahydrocannabinol (THC) and anandamide, induce dose-related immunosuppression in both the primary and secondary in vitro plaque-forming cell assays of antibody formation. The immunosuppression induced by both compounds could be blocked by SR144528, an antagonist specific for the CB(2) receptor, but not by SR141716, a CB(1) antagonist. These studies are novel in that they show that both anandamide and THC are active in the nanomolar to picomolar (for anandamide) range in these assays of immune function, and that both mediate their effects directly on cells of the immune system through the CB(2) receptor.

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. Publishing Authors By Initials

TK Eisenstein,JJ Meissler,Q Wilson,JP Gaughan,MW Adler,

For similar organic chemicals: hydrocarbons: terpenes: cannabinoids: tetrahydrocannabinol research abstracts see: organic chemicals: hydrocarbons: terpenes: cannabinoids: tetrahydrocannabinol research

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Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neuroimmunology

VOLUME: 189

Page Numbers: 17-22

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 19

MONTH: 07

YEAR: 2007

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109498

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. Keywords Mesh Terms:

KEYWORDS: Tetrahydrocannabinol

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. Information

Substance Name: anandamide

Registry Number: 94421-68-8

Grant and Affiliation Information for Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.

AFFILIATION: Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, United States. tke@temple.edu

Country: Netherlands

AGENCY: United States NIDA

GRANT: DA13429

ACRONYM: DA

MEDLINETA: J Neuroimmunol

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