Analyzing proteomes and protein function using graphical comparative analysis of tandem mass spectrometry results.

Analyzing proteomes and protein function using graphical comparative analysis of tandem mass spectrometry results. Research Abstract Details 

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Analyzing proteomes and protein function using graphical comparative analysis of tandem mass spectrometry results. Abstract Text:

K Jill McAfee,Dexter T Duncan,Michael Assink,Andrew J Link,

Although generating large amounts of proteomic data using tandem mass spectrometry has become routine, there is currently no single set of comprehensive tools for the rigorous analysis of tandem mass spectrometry results given the large variety of possible experimental aims. Currently available applications are typically designed for displaying proteins and posttranslational modifications from the point of view of the mass spectrometrist and are not versatile enough to allow investigators to develop biological models of protein function, protein structure, or cell state. In addition, storage and dissemination of mass spectrometry-based proteomic data are problems facing the scientific community. To address these issues, we have developed a relational database model that efficiently stores and manages large amounts of tandem mass spectrometry results. We have developed an integrated suite of multifunctional analysis software for interpreting, comparing, and displaying these results. Our system, Bioinformatic Graphical Comparative Analysis Tools (BIGCAT), allows sophisticated analysis of tandem mass spectrometry results in a biologically intuitive format and provides a solution to many data storage and dissemination issues.

Analyzing proteomes and protein function using graphical comparative analysis of tandem mass spectrometry results. Publishing Authors By Initials

KJ McAfee,DT Duncan,M Assink,AJ Link,

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Analyzing proteomes and protein function using graphical comparative analysis of tandem mass spectrometry results. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular & cellular proteomics : MCP

VOLUME: 5

Page Numbers: 1497-513

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ISSN: 1535-9476

DAY: 16

MONTH: 05

YEAR: 2006

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LANGUAGE: eng

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Grant and Affiliation Information for Analyzing proteomes and protein function using graphical comparative analysis of tandem mass spectrometry results.

AFFILIATION: Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2363, USA.

Country: United States

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MEDLINETA: Mol Cell Proteomics

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