[Analysis with DNA chips of the changes of gene expressions in K562 cells in response to As2O3 treatment]

[Analysis with DNA chips of the changes of gene expressions in K562 cells in response to As2O3 treatment] Research Abstract Details 

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[Analysis with DNA chips of the changes of gene expressions in K562 cells in response to As2O3 treatment] Abstract Text:

Chun-qiong Feng,Wen-li Ma,Ling Li,Yan-bin Song,Rong Shi,Qing-hua Wu,Qiu-ye Guo,Ji Zhu,Wen-ling Zheng,

OBJECTIVE: To investigate differential gene expression in apoptotic cells induced by As(2)O(3), and identify novel apoptosis-related genes. METHOD: Apoptosis of K562 cells cultured in RPMI 1640 medium supplemented with 10 % calf serum was induced by As(2)O(3). Total RNA of the apoptotic and normal cells were then extracted, purified and subject to reverse transcription into first-strand cDNA, labeled with Cy3/Cy5. Placenta DNA microarrays containing 348 DNA fragments were used to analyze the changes in gene expressions in the cells treated with As(2)O(3).RESULT: Eleven differentially expressed genes were identified in the apoptotic cells in comparison with the normal cells, 3 of which were associated with apoptosis, while the others were related to cell growth and proliferation. CONCLUSION: The placenta DNA microarrays we constructed may well apply to the analysis of the differentially expressed genes.

[Analysis with DNA chips of the changes of gene expressions in K562 cells in response to As2O3 treatment] Publishing Authors By Initials

CQ Feng,WL Ma,L Li,YB Song,R Shi,QH Wu,QY Guo,J Zhu,WL Zheng,

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[Analysis with DNA chips of the changes of gene expressions in K562 cells in response to As2O3 treatment] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Di 1 jun yi da xue xue bao = Academic journal of t

VOLUME: 22

Page Numbers: 772-5

Journal Abbreviation: Di Yi Jun Yi Da Xue Xue Bao

ISSN: 1000-2588

DAY: 25

MONTH: Sep

YEAR: 2002

[Analysis with DNA chips of the changes of gene expressions in K562 cells in response to As2O3 treatment] Information

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LANGUAGE: chi

NlmUniqueID: 9426110

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AFFILIATION: Institute of Molecular Biology, First Military Medical University, Guangzhou 510515, China. feng1215@fimmu.com

Country: China

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MEDLINETA: Di Yi Jun Yi Da Xue Xue Bao

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