Analysis of viral infection in patients with IgA nephropathy.

Analysis of viral infection in patients with IgA nephropathy. Research Abstract Details 

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Analysis of viral infection in patients with IgA nephropathy. Abstract Text:

M Kunimoto,Y Hayashi,K Kuki,M Mune,Y Yamada,S Tamura,I Takano,K Fujiwara,Y Akagi,T Samukawa,

We investigated viral infections in the tonsils, pharynx and renal tissues of patients with IgA nephropathy using cell culture, polymerase chain reaction (PCR) and immuno-fluorescent techniques, and measured antibody titers against numerous types of viruses. Neutralization tests found no significant inhibition of growth of adenovirus-1, 2, 3, 4, 5, 6, 7, 11 or 19, Coxsackie virus-A7, A9, A16, B1, B2, B3, B4, B5 or B6, or RS virus. Swabs of the oral cavity of patients with IgA nephropathy were cultured with Hel cells, MDCK cells, FL cells, BHK-21 cells and RD-18S cells. No cytopathic effect was detected in any of these cell cultures. We failed to detect the presence of herpes simplex virus-1 and -2, varicella-zoster virus, cytomegalovirus and Epstein-Barr virus (EBV)-1 and -2 in tonsils, renal tissues and mouthwashings from patients with IgA nephropathy. On the other hand, EBV alone was detected with the PCR technique, in mouthwashings from 6 out of 14 patients with IgA nephropathy (42%). Immunohistological and serological analyses were done to examine the relationship between EBV and IgA nephropathy. No evidence was obtained that EBV-infected B lymphocytes were producing IgA. It seems unlikely that the viral infections examined in this study play a significant role in the pathogenesis of IgA nephropathy.

Analysis of viral infection in patients with IgA nephropathy. Publishing Authors By Initials

M Kunimoto,Y Hayashi,K Kuki,M Mune,Y Yamada,S Tamura,I Takano,K Fujiwara,Y Akagi,T Samukawa,

For similar virus diseases research abstracts see: virus diseases research

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Analysis of viral infection in patients with IgA nephropathy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 508

Page Numbers: 11-8

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1993

Analysis of viral infection in patients with IgA nephropathy. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Analysis of viral infection in patients with IgA nephropathy. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Analysis of viral infection in patients with IgA nephropathy. Information

Substance Name: Antibodies, Viral

Registry Number: 0

Grant and Affiliation Information for Analysis of viral infection in patients with IgA nephropathy.

AFFILIATION: Department of Otorhinolaryngology, Wakayama Medical College, Japan.

Country: SWEDEN

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MEDLINETA: Acta Otolaryngol Suppl

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