Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients.

Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. Abstract Text:

Joan H Pedersen-Lane,Robert B Zurier,David A Lawrence,

Although the exact etiology of rheumatoid arthritis (RA) remains unknown, there is increasing evidence that reactive oxygen species and a pro-oxidant/antioxidant imbalance are an important part of the pathogenesis of joint tissue injury. Flow cytometry was used to evaluate the thiol status [surface-thiols and intracellular glutathione (iGSH)] of leukocytes from RA patients and controls. Levels of surface-thiols and iGSH of leukocytes from RA patients were significantly lower than of leukocytes from controls. CD53, a glycoprotein of the tetraspanin superfamily, which coprecipitates with the GSH recycling enzyme gamma-glutamyl transpeptidase, was elevated significantly on leukocytes from RA patients compared with leukocytes from controls. Surface-thiols and GSH play important roles in redox buffering of cells, providing protection from oxidative stress. The chronic inflammation of RA has been associated with oxidative stress, which is shown to cause a decline in the levels of cellular antioxidant sulfhydryls (R-SH). As antioxidant-protective levels also decline with age, the problem is compounded in older RA patients, who did have fewer R-SH. Chronic stress can also have an effect on telomere lengths, determining cell senescence and longevity. Although telomeres shorten with increasing age, our flow cytometry studies indicate that accelerated shortening in telomere lengths occurs with increasing age of RA patients, suggesting premature cellular aging. The paradox is that lymphocytes from RA patients are believed to resist apoptosis, and we suggest that the elevated expression of CD53, which results from the increased oxidative stress, may protect against apoptosis.

Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. Publishing Authors By Initials

JH Pedersen-Lane,RB Zurier,DA Lawrence,

For similar chromosome structures: telomere research abstracts see: chromosome structures: telomere research

PUBMED ID PMID:

MEDLINE DATE:

Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of leukocyte biology

VOLUME: 81

Page Numbers: 934-41

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 8

MONTH: 01

YEAR: 2007

Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8405628

Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. Keywords Mesh Terms:

KEYWORDS: Telomere

MESH TERMS: chemistry

Chemical & Substance for Abstract: Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. Information

Substance Name: Sulfhydryl Compounds

Registry Number: 0

Grant and Affiliation Information for Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients.

AFFILIATION: Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509, USA.

Country: United States

AGENCY: United States NCCAM

GRANT: R01-AT00309

ACRONYM: AT

MEDLINETA: J Leukoc Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients Related Publications

• A pilot study of [18F]fluorodeoxyglucose positron emission tomography scans during and after radiation-based therapy in patients with non small-cell lung cancer.
• Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy.
• An Impulse-Response Model using Pace and Duration Correlates to Performance of a 1500 m Olympic Finalist: 1416: Board #179 May 30 11:00 AM -12:30 PM.
• An evaluation of the seasonality of veterinary treatments for lameness in UK dairy cattle.
• Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients.
• Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of IFN-gamma production by phagocytic cells.
• BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin.
• BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.
• Central overexpression of angiotensin AT(1A) receptors prevents dopamine D(2) receptor regulation of alcohol consumption in mice.
• Cr04 six year, prospective analysis of rectal bleeding clinics at the queen elizabeth hospital, adelaide, South australia.
• Environmental toxins as modulators of antiviral immune responses.
• Evidence that the Pim1 kinase gene is a direct target of HOXA9.
• Heartbeat perception in depression.
• Housing system, milk production, and zero-grazing effects on lameness and leg injury in dairy cows.
• Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.
• Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
• Lead effects on development and function of bone marrow-derived dendritic cells promote Th2 immune responses.
• Light-regulated sampling of protein tyrosine kinase activity.
• Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor.
• Open access publication is growing in importance.
• PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
• Propagating uncertainty in microarray data analysis.
• Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response.
• Sterols of Delphinium ajacis; Production and Metabolic Relationships in Whole Plants and Callus Tissue*.
• The Gibbs Centroid Sampler.
• The clinical application of intensity-modulated radiation therapy.
• The contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and smooth muscle cell adhesion to vitronectin.
• The extent and severity of vascular leakage as evidence of tumor aggressiveness in high-grade gliomas.
• Twinning in mares: A survey of veterinarians and analyses of theriogenology records.
• Wettability modification and the subsequent manipulation of protein adsorption on a Ti6Al4V alloy by means of CO2 laser surface treatment.