Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues.

Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues. Research Abstract Details 

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Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues. Abstract Text:

In the search for new brain imaging agents for the use with single photon emission computed tomography (SPECT), quantitative structure activity relationship (QSAR) analysis of the correlations between initial brain uptake and physicochemical parameters like lipophilicity, log P, molecular weight, log MW and log U/D (undissociated/dissociated), of the 99mTc-DADT (diaminedithiol) complexes and 99mTc-PAO (propyleneamineoxime) complexes have been analyzed. High correlations are found for both the 99mTc-DADT complexes (r = 0.94) and for the 99mTc-PAO complexes (r = 0.83) which are significant at 99.9 and 99.5 percentile level, respectively. These results will help the further design of better ligands for 99mTc in brain imaging.

Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues. Publishing Authors By Initials

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Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of radiation applications an

VOLUME: 42

Page Numbers: 503-8

Journal Abbreviation:

ISSN: 0883-2889

DAY: 26

MONTH: 02

YEAR: 1991

Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues. Information

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LANGUAGE: eng

NlmUniqueID: 8611097

Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues. Information

Substance Name: technetium Tc 99m propylene amine oxime

Registry Number: 0

Grant and Affiliation Information for Analysis of the quantitative structure activity relationship of technetium-99m-labeled diaminedithiol (DADT) and propylene-amine-oxime (PAO) brain blood flow analogues.

AFFILIATION: School of Pharmacy, Pharmaceutics and Medicinal Chemistry, Radiology Department, University of Southern California, Los Angeles 90033.

Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum [A]

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