Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein.

Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein. Research Abstract Details 

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Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein. Abstract Text:

R P Kamal,C Tosh,B Pattnaik,P Behera,S Nagarajan,S Gounalan,N Shrivastava,B P Shankar,H K Pradhan,

Outbreaks of highly pathogenic avian influenza (HPAI) H5N1 virus were reported for the first time in India during February 2006. Herein, we have sequenced and analyzed the PB2 genes of five influenza virus isolates obtained from three affected states (Gujarat, Madhya Pradesh and Maharashtra) in India during the outbreaks. In the phylogenetic analysis, the Indian isolates were grouped in the mixed-migratory bird sub-lineage of the Eurasian lineage. From the phylogenetic tree, it is evident that viruses were probably introduced to India from China via Europe because they share a direct ancestral relationship with the Indian isolates. The virus might have spread through migratory waterfowls that survived the HPAI H5N1 infection. These viruses were able to replicate in cultured cells of avian and mammalian hosts and posses lysine at position 627 of the PB2 protein, indicating that they might be able to cross the host barrier to infect mammals.

Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein. Publishing Authors By Initials

RP Kamal,C Tosh,B Pattnaik,P Behera,S Nagarajan,S Gounalan,N Shrivastava,BP Shankar,HK Pradhan,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of virology

VOLUME: 152

Page Numbers: 1637-44

Journal Abbreviation: Arch. Virol.

ISSN: 0304-8608

DAY: 11

MONTH: 06

YEAR: 2007

Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein. Information

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LANGUAGE: eng

NlmUniqueID: 7506870

Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein. Information

Substance Name: Lysine

Registry Number: 56-87-1

Grant and Affiliation Information for Analysis of the PB2 gene reveals that Indian H5N1 influenza virus belongs to a mixed-migratory bird sub-lineage possessing the amino acid lysine at position 627 of the PB2 protein.

AFFILIATION: High Security Animal Disease Laboratory (A National Referral Facility), Indian Veterinary Research Institute, Anand Nagar, Bhopal, India.

Country: Austria

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MEDLINETA: Arch Virol

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