Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Research Abstract Details 

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Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Abstract Text:

Latorya D Hicks,Janice L Hyatt,Teri Moak,Carol C Edwards,Lyudmila Tsurkan,Monika Wierdl,Antonio M Ferreira,Randy M Wadkins,Philip M Potter,

We have synthesized and assessed the ability of symmetrical fluorobenzoins and fluorobenzils to inhibit mammalian carboxylesterases (CE). The majority of the latter were excellent inhibitors of CEs however unexpectedly, the fluorobenzoins were very good enzyme inhibitors. Positive correlations were seen with the charge on the hydroxyl carbon atom, the carbonyl oxygen, and the Hammett constants for the derived K(i) values with the fluorobenzoins.

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Publishing Authors By Initials

LD Hicks,JL Hyatt,T Moak,CC Edwards,L Tsurkan,M Wierdl,AM Ferreira,RM Wadkins,PM Potter,

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Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry

VOLUME: 15

Page Numbers: 3801-17

Journal Abbreviation:

ISSN: 0968-0896

DAY: 12

MONTH: 03

YEAR: 2007

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9413298

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Keywords Mesh Terms:

KEYWORDS: Quantitative Structure-Activity Relation

MESH TERMS: chemistry

Chemical & Substance for Abstract: Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Information

Substance Name: Carboxylic Ester Hydrolases

Registry Number: EC 3.1.1.-

Grant and Affiliation Information for Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

AFFILIATION: Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Country: England

AGENCY: United States NIDA

GRANT: R01 DA018116-02

ACRONYM: DA

MEDLINETA: Bioorg Med Chem

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