Analysis of repeated bouts of measurements in the framework of generalized estimating equations.

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Analysis of repeated bouts of measurements in the framework of generalized estimating equations. Abstract Text:

Justine Shults,Carissa A Mazurick,J Richard Landis,

We consider a longitudinal study of interstitial cystitis (IC) in women, in which the time between bouts of repeated measurements is large relative to the within-bout separation in time. Our outcome of interest is the number of nocturnal voids that we model via quasi-least squares (QLS) in the framework of generalized estimating equations (GEE). To account for potential intra-subject correlation, we directly apply a banded Toeplitz correlation structure that previously was only implemented in an ad hoc approach using GEE. We describe this structure, its appropriateness for data from the IC study, and the results of our analysis. We then demonstrate that correct specification of the underlying correlation structure versus incorrectly applying a simpler structure can prevent substantial losses in efficiency in estimation of the regression parameter. These comparisons involve the limiting values of the estimates of the correlation parameters, which are not consistent for the misspecification scenarios considered here. We therefore obtain the limiting values of the QLS estimates when the structure is incorrectly specified.

Analysis of repeated bouts of measurements in the framework of generalized estimating equations. Publishing Authors By Initials

J Shults,CA Mazurick,J Richard Landis,

For similar reproductive and urinary physiology: urinary tract physiology: urination research abstracts see: reproductive and urinary physiology: urinary tract physiology: urination research

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Analysis of repeated bouts of measurements in the framework of generalized estimating equations. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Statistics in medicine

VOLUME: 25

Page Numbers: 4114-28

Journal Abbreviation:

ISSN: 0277-6715

DAY: 15

MONTH: Dec

YEAR: 2006

Analysis of repeated bouts of measurements in the framework of generalized estimating equations. Information

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LANGUAGE: eng

NlmUniqueID: 8215016

Analysis of repeated bouts of measurements in the framework of generalized estimating equations. Keywords Mesh Terms:

KEYWORDS: Urination

MESH TERMS: physiology

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Grant and Affiliation Information for Analysis of repeated bouts of measurements in the framework of generalized estimating equations.

AFFILIATION: Department of Biostatistics and Epidemiology, Centre for Clinical Epidemiology & Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA. jshults@cceb.upenn.edu

Country: England

AGENCY: United States NIDDK

GRANT: R01DK59601

ACRONYM: DK

MEDLINETA: Stat Med

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