Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products.

Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Research Abstract Details 

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Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Abstract Text:

David M Holloway,Lionel G Harrison,David Kosman,Carlos E Vanario-Alonso,Alexander V Spirov,

We analyze the relation between maternal gradients and segmentation in Drosophila, by quantifying spatial precision in protein patterns. Segmentation is first seen in the striped expression patterns of the pair-rule genes, such as even-skipped (eve). We compare positional precision between Eve and the maternal gradients of Bicoid (Bcd) and Caudal (Cad) proteins, showing that Eve position could be initially specified by the maternal protein concentrations but that these do not have the precision to specify the mature striped pattern of Eve. By using spatial trends, we avoid possible complications in measuring single boundary precision (e.g., gap gene patterns) and can follow how precision changes in time. During nuclear cleavage cycles 13 and 14, we find that Eve becomes increasingly correlated with egg length, whereas Bcd does not. This finding suggests that the change in precision is part of a separation of segmentation from an absolute spatial measure, established by the maternal gradients, to one precise in relative (percent egg length) units.

Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Publishing Authors By Initials

DM Holloway,LG Harrison,D Kosman,CE Vanario-Alonso,AV Spirov,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental dynamics : an official publication o

VOLUME: 235

Page Numbers: 2949-60

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 3

MONTH: Nov

YEAR: 2006

Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Information

Substance Name: even-skipped protein, Drosophila

Registry Number: 108911-13-3

Grant and Affiliation Information for Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products.

AFFILIATION: Mathematics Department, British Columbia Institute of Technology, Burnaby, BC, Canada. David_Holloway@bcit.ca

Country: United States

AGENCY: United States NIGMS

GRANT: 1-R01-GM072022-01

ACRONYM: GM

MEDLINETA: Dev Dyn

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