Analysis of opioid peptides by on-line SPE-CE-ESI-MS.

Analysis of opioid peptides by on-line SPE-CE-ESI-MS. Research Abstract Details 

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Analysis of opioid peptides by on-line SPE-CE-ESI-MS. Abstract Text:

Elena ,Fernando Benavente,Victoria Sanz-Nebot, Barbosa,

In this study, SPE-CE-ESI-MS is explored for the preconcentration and separation of dilute solutions of six opioid peptides. First, a CE-ESI-MS methodology was developed and validated. LODs of around 1 microg/mL were obtained for all the studied peptides. For SPE-CE-ESI-MS experiments, a home-made SPE microcartridge containing a C18 sorbent was constructed near the inlet of the separation capillary. After optimizing the on-line preconcentration methodology, LODs between 10 and 0.1 ng/mL were achieved. Repeatability, reproducibility, durability of the microcartridges and linearity of the SPE-CE-ESI-MS methodology were also investigated and compared to the values obtained by CE-ESI-MS. Finally, human plasma samples fortified with opioid peptides were analyzed by SPE-CE-ESI-MS in order to show the potential of the methodology for the analysis of biological fluids.

Analysis of opioid peptides by on-line SPE-CE-ESI-MS. Publishing Authors By Initials

E ,F Benavente,V Sanz-Nebot,J Barbosa,

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Analysis of opioid peptides by on-line SPE-CE-ESI-MS. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Electrophoresis

VOLUME: 28

Page Numbers: 3957-65

Journal Abbreviation: Electrophoresis

ISSN: 0173-0835

DAY: 31

MONTH: Nov

YEAR: 2007

Analysis of opioid peptides by on-line SPE-CE-ESI-MS. Information

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LANGUAGE: eng

NlmUniqueID: 8204476

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Chemical & Substance for Abstract: Analysis of opioid peptides by on-line SPE-CE-ESI-MS. Information

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Grant and Affiliation Information for Analysis of opioid peptides by on-line SPE-CE-ESI-MS.

AFFILIATION: Department of Analytical Chemistry, University of Barcelona, Barcelona, Spain.

Country: Germany

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MEDLINETA: Electrophoresis

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