Analysis of nitric oxide synthase genes in cluster headache.

Analysis of nitric oxide synthase genes in cluster headache. Research Abstract Details 

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Analysis of nitric oxide synthase genes in cluster headache. Abstract Text:

C Sjöstrand,H Modin,T Masterman,K Ekbom,E Waldenlind,J Hillert,

The aetiology of cluster headache is still not yet completely understood, but the potential relevance of genetic factors has been recognized during recent years. Nitric oxide (NO) plays a critical role in the regulation of vasodilation, neurotransmission, inflammation and many other events throughout the body. NO also appears to be an important mediator of vascular headache pathophysiology. In this study we have performed an association analysis of five polymorphic microsatellite markers in the three different NO synthase (NOS) genes; nNOS (NOS1), iNOS (NOS2A) and eNOS (NOS3). Ninety-one cluster headache patients diagnosed according to International Headache Society criteria and 111 matched controls were studied. Phenotype and allele frequencies were similarly distributed in patients and controls except for an iNOS (NOS2A) pentanucleotide repeat allele which was significantly more common in controls. We observed a higher phenotype frequency of this allele in our control group compared with rates in control groups of other studies, whereas the frequency in our patients was similar to that in controls from previous reports. Thus, we conclude that it is unlikely that genetic variations within the NOS genes contribute greatly to cluster headache susceptibility.

Analysis of nitric oxide synthase genes in cluster headache. Publishing Authors By Initials

C Sjöstrand,H Modin,T Masterman,K Ekbom,E Waldenlind,J Hillert,

For similar genetic phenomena: phenotype research abstracts see: genetic phenomena: phenotype research

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Analysis of nitric oxide synthase genes in cluster headache. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cephalalgia : an international journal of headache

VOLUME: 22

Page Numbers: 758-64

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Nov

YEAR: 2002

Analysis of nitric oxide synthase genes in cluster headache. Information

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LANGUAGE: eng

NlmUniqueID: 8200710

Analysis of nitric oxide synthase genes in cluster headache. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: genetics

Chemical & Substance for Abstract: Analysis of nitric oxide synthase genes in cluster headache. Information

Substance Name: Nitric Oxide Synthase Type III

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Analysis of nitric oxide synthase genes in cluster headache.

AFFILIATION: Department of Neurology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden. christina.sjostrand@neurotek.ki.se

Country: England

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MEDLINETA: Cephalalgia

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