Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture.

Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture. Research Abstract Details 

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Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture. Abstract Text:

Lukasz Wicherek,Krystyna Galazka,Agata Lazar,Lukasz Wicherek,Krystyna Galazka,Agata Lazar,Lukasz Wicherek,Krystyna Galazka,Agata Lazar,

Introduction: Tubal rupture seems to be linked to a disturbance in maternal immune response and trophoblast cell invasion. The immunomodulating activity of endometrial cells is necessary for the coexistence of activated immune cells and endometrial cells. RCAS1 and metallothionein (MT) participate in this process. Material and Methods: Tissue samples derived from fallopian tubes and endometrium were collected during one surgical procedure and divided into three groups: unruptured ectopic pregnancy (EP) without bleeding, unruptured EP with hemorrhage into the peritoneal cavity, and ruptured tubal pregnancy. Immunoreactivity of MT, RCAS1, CD56, CD3, CD69 and CD25 were assessed by immunohistochemical methods. Results: The number of CD3+ and CD56+ cells as well as CD69 antigen immunoreactivity in ruptured tubal mucosa of EP were statistically significantly higher than those measured for unruptured EP without bleeding, while at the same time the number of CD56+ cells in endometrium was statistically significantly lower. The growth of immune cell numbers in tubal mucosa during tubal rupture was not associated with an adequate MT and RCAS1 level. Conclusion: Tubal perforation seems to be linked to a concentration of immune cells and a growth of their activity without an adequate increase of the level of proteins compensating for immune cell response. Copyright (c) 2007 S. Karger AG, Basel.

Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture. Publishing Authors By Initials

L Wicherek,K Galazka,A Lazar,L Wicherek,K Galazka,A Lazar,L Wicherek,K Galazka,A Lazar,

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Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gynecologic and obstetric investigation

VOLUME: 65

Page Numbers: 52-61

Journal Abbreviation: Gynecol. Obstet. Invest.

ISSN: 1423-002X

DAY: 24

MONTH: 08

YEAR: 2007

Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture. Information

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LANGUAGE: eng

NlmUniqueID: 7900587

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Grant and Affiliation Information for Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture.

AFFILIATION: Department of Gynecology, Obstetrics and Oncology, Jagiellonian University, Krakow, Poland.

Country: Switzerland

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MEDLINETA: Gynecol Obstet Invest

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