Analysis of lactation defects in transgenic mice.

Analysis of lactation defects in transgenic mice. Research Abstract Details 

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Analysis of lactation defects in transgenic mice. Abstract Text:

Carol A Palmer,Margaret C Neville,Steven M Anderson,James L McManaman,

Although lactation is the only physiological function of the mammary gland, little is known about the molecular events required for secretory activation and milk production. Genetically altered mice have been used extensively to study mammary gland development during puberty and pregnancy, as well as mammary tumorigenesis. A number of approaches have been used to produce genetic modifications in mammary glands of mice, including transgenic mice utilizing mammary specific promoters, traditional knockout mice, mammary-specific gene deletion, and conditionally-regulated transgenes. The same technologies can be used to study secretory activation and lactation; however only a comparatively small number of studies to date have used these approaches to study these events. In this paper we review the technologies available to make genetically modified mice for the study of secretory activation and lactation as well as specific analytical procedures that can be used to characterize mice with lactation defects.

Analysis of lactation defects in transgenic mice. Publishing Authors By Initials

CA Palmer,MC Neville,SM Anderson,JL McManaman,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: regulatory sequences, nucleic acid: promoter regions (genetics) research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: regulatory sequences, nucleic acid: promoter regions (genetics) research

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Analysis of lactation defects in transgenic mice. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of mammary gland biology and neoplasia

VOLUME: 11

Page Numbers: 269-82

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ISSN: 1083-3021

DAY: 3

MONTH: Oct

YEAR: 2006

Analysis of lactation defects in transgenic mice. Information

Number of References: 71

LANGUAGE: eng

NlmUniqueID: 9601804

Analysis of lactation defects in transgenic mice. Keywords Mesh Terms:

KEYWORDS: Promoter Regions (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for Analysis of lactation defects in transgenic mice.

AFFILIATION: Department of Physiology, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, CO 80045, USA.

Country: United States

AGENCY: United States NICHD

GRANT: R01 HD045965

ACRONYM: HD

MEDLINETA: J Mammary Gland Biol Neoplasia

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