Analysis of HNE metabolism in CNS models.

Analysis of HNE metabolism in CNS models. Research Abstract Details 

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Analysis of HNE metabolism in CNS models. Abstract Text:

Alena Kubatova,Ales Honzatko,Jiri Brichac,Eric Long,Matthew J Picklo,

The formation and toxicity of trans-4-hydroxy-2-nonenal in the central nervous system is well documented. However, the metabolism of HNE in the central nervous system (CNS) is not clear. HNE metabolism in the CNS appears to be different from that in other tissues and organs and may be dependent on the cell type and subcellular environment. Our data show that HNE metabolism is affected by the stereocenter of HNE and that oxidation of HNE may be a primary route of metabolism. Further metabolic analysis of HNE disposition is needed to clarify which pathways are truly important in normal and pathological states in the CNS.

Analysis of HNE metabolism in CNS models. Publishing Authors By Initials

A Kubatova,A Honzatko,J Brichac,E Long,MJ Picklo,

For similar nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders: parkinson disease research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders: parkinson disease research

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Analysis of HNE metabolism in CNS models. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Redox report : communications in free radical rese

VOLUME: 12

Page Numbers: 16-9

Journal Abbreviation: Redox Rep.

ISSN: 1743-2928

DAY: 3

MONTH: 12

YEAR: 2007

Analysis of HNE metabolism in CNS models. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9511366

Analysis of HNE metabolism in CNS models. Keywords Mesh Terms:

KEYWORDS: Parkinson Disease

MESH TERMS: metabolism

Chemical & Substance for Abstract: Analysis of HNE metabolism in CNS models. Information

Substance Name: 4-hydroxy-2-nonenal

Registry Number: 29343-52-0

Grant and Affiliation Information for Analysis of HNE metabolism in CNS models.

AFFILIATION: Department of Chemistry, University of North Dakota, Grand Forks, North Dakota 58203, USA.

Country: England

AGENCY: United States NCRR

GRANT: P20 RR17699-01

ACRONYM: RR

MEDLINETA: Redox Rep

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