[Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering]

[Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering] Abstract Text:

Li Li,Xia Li,Yi-Han Chen,Zheng Guo,Wei Jiang,Rui-Jie Zhagn,Shao-Qi Rao,

Microarray technology has proposed a powerful tool in dealing with the heterogeneity of disease. Currently, many methods in the field are based on traditional hierarchical clustering to discover subtypes of disease using a large number of genes on microarray.However, they did not considered that large unrelated noise (genes)may mask significant partitions and correlations of disease samples. To avoid the shortcoming, this paper presented a heterogeneous analysis based on coupled two-way clustering (HCTWC) to search interesting gene signature and find the natural partitions of disease samples. The method was applied to diffuse large B-cell lymphoma (DLBCL) microarray dataset. By identifying significant gene signature, we were able to discover the two new subtypes of DLBCL with survival rate 55% and 25% respectively. The results showed that HCTWC had the potential to be a powerful tool for solving the heterogeneity of disease on gene expression profile.

[Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering] Publishing Authors By Initials

L Li,X Li,YH Chen,Z Guo,W Jiang,RJ Zhagn,SQ Rao,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Yi chuan = Hereditas / Zhongguo yi chuan xue hui b

VOLUME: 28

Page Numbers: 1129-34

Journal Abbreviation:

ISSN: 0253-9772

DAY: 11

MONTH: Sep

YEAR: 2006

[Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9436478

[Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering]

AFFILIATION: Institute of Medical Genetics, Tongji Unversity, Shanghai, China. flylily322@hotmail.com

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Yi Chuan

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering Related Publications

• A common neural progenitor for the CNS and PNS.
• Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate.
• Age-related functional recruitment for famous name recognition: an event-related fMRI study.
• An FMRI analysis of the human hippocampus: inference, context, and task awareness.
• An Intelligent 802.11 Triage Tag for medical response to disasters.
• Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex.
• Changes in Behavior and Brain Acetylcholinesterase Activity in Mosquito Fish, Gambusia affinis in Response to the Sub-Lethal Exposure to Chlorpyrifos.
• Development and Validation of Liquid Chromatographic and UV Derivative Spectrophotometric Methods for the Determination of Famciclovir in Pharmaceutical Dosage Forms.
• Effect of glycerol level in Tris-basek extender and equilibration period on quality of frozen goat semen.
• Embryonic expression and extracellular secretion of Xenopus slit.
• Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells.
• Inhibition by the bioflavonoid ternatin of aflatoxin B1-induced lipid peroxidation in rat liver.
• Ion imprinted polymer particles for separation of yttrium from selected lanthanides.
• Medial temporal lobe activity for recognition of recent and remote famous names: an event-related fMRI study.
• Outbreak of killer brain disease in children.
• Perspectives in medical education--1. Reflections on the state of medical education in Japan.
• Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.
• Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.
• Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture.
• THE ORNITHOPHILIC BLACK FLY SIMULIUM MERIDIONALE RILEY (DIPTERA: SIMULIIDAE) FEEDING IN MAN DURING AUTUMN.
• The expression of TNF-alpha mRNA and its significance in murine viral myocarditis.
• The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.
• The secreted product of Xenopus gene lunatic Fringe, a vertebrate signaling molecule.
• [Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering]
• [Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance]
• [Inhibitive effects of gastric cancer cell-dendritic cell fusion vaccine on tumor cell proliferation cycle]
• [Ion-exchange chromatographic behavior and characterization of Staphylococcus aureus in exponential phase]
• [Major constituent proteins in donkey hide and their interaction]
• [Reaction of atrazine with protein and its application to detection of protein]
• fMRI of healthy older adults during Stroop interference.