Analysis of CoQ(10) in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration.

Analysis of CoQ(10) in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. Research Abstract Details 

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Analysis of CoQ(10) in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. Abstract Text:

Lie Li,Deepthi Pabbisetty,Paulo Carvalho,Mitchell A Avery,Bonnie A Avery,Lie Li,Deepthi Pabbisetty,Paulo Carvalho,Mitchell A Avery,Bonnie A Avery,

A UPLC-MS method for determining Coenzyme Q(10) (CoQ(10)) levels in rat serum was developed. CoQ(10) was quantitatively extracted into 2-propanol using a fast extraction procedure. The separation of CoQ(10) was performed on a Waters Acquity UPLCtrade mark BEH C(18) column (1.7mum, 1.0mmx50mm) with the mobile phase containing acetonitrile, 2-propanol, and formic acid (90:10:0.1) over 5min. The sensitivity of this method allows for the quantitation of 50ng/mL CoQ(10) in serum (S/N=10). The linearity of this method was found to be from 50 to 20,000ng/mL. The precision was less than 10% (intra- and inter-day), and the average extraction recovery was between 90 and 105%. This procedure provides a precise, sensitive and direct assay method for the determination of CoQ(10) in rat serum after oral administration. This method could be applied to further pharmacokinetic studies of CoQ(10).

Analysis of CoQ(10) in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. Publishing Authors By Initials

L Li,D Pabbisetty,P Carvalho,MA Avery,BA Avery,L Li,D Pabbisetty,P Carvalho,MA Avery,BA Avery,

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Analysis of CoQ(10) in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 46

Page Numbers: 137-42

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ISSN: 0731-7085

DAY: 23

MONTH: 10

YEAR: 2007

Analysis of CoQ(10) in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Analysis of CoQ(10) in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration.

AFFILIATION: Department of Pharmaceutics, School of Pharmacy, University of Mississippi, University, MS 38677, USA.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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