Analysis of Changes in the Total Lymphocyte and Eosinophil Count during Immunotherapy for Metastatic Renal Cell Carcinoma: Correlation with Response and Survival.

Analysis of Changes in the Total Lymphocyte and Eosinophil Count during Immunotherapy for Metastatic Renal Cell Carcinoma: Correlation with Response and Survival. Research Abstract Details 

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Analysis of Changes in the Total Lymphocyte and Eosinophil Count during Immunotherapy for Metastatic Renal Cell Carcinoma: Correlation with Response and Survival. Abstract Text:

In Gab Jeong,Kyung Seok Han,Jae Young Joung,Woo Suk Choi,Seung Sik Hwang,Seung Ok Yang,Ho Kyung Seo,Jinsoo Chung,Kang Hyun Lee,In Gab Jeong,Kyung Seok Han,Jae Young Joung,Woo Suk Choi,Seung Sik Hwang,Seung Ok Yang,Ho Kyung Seo,Jinsoo Chung,Kang Hyun Lee,In Gab Jeong,Kyung Seok Han,Jae Young Joung,Woo Suk Choi,Seung Sik Hwang,Seung Ok Yang,Ho Kyung Seo,Jinsoo Chung,Kang Hyun Lee,In Gab Jeong,Kyung Seok Han,Jae Young Joung,Woo Suk Choi,Seung Sik Hwang,Seung Ok Yang,Ho Kyung Seo,Jinsoo Chung,Kang Hyun Lee,

The aims of this study were to analyze lymphocyte and eosinophil counts in consecutive peripheral blood samples taken during immunotherapy for metastatic renal cell carcinoma (mRCC) and to correlate the findings with objective response and survival. A total of 40 patients with mRCC who received immunotherapy with interleukin-2, interferon-alpha, and 5-fluorouracil were analyzed. Objective responses were observed in 14 patients, including 2 (5%) who showed a complete response (CR) and 12 (30%) who showed a partial response (PR). Eleven patients (27%) achieved stable disease (SD), and 15 patients (38%) had progressive disease (PD). Changes from baseline in the total lymphocyte counts were significantly higher in the responding patients (CR+PR+SD) than in the non-responding patients (PD) (p=0.017), but no difference was seen in the total eosinophil counts (p=0.275). Univariate analysis identified the Eastern Cooperative Oncology Group (ECOG) performance status (p=0.017), the presence of a primary renal tumor (p<0.001) and the peripheral lymphocyte counts at week 4 (p=0.034) as prognostic factors, but a low ECOG performance status (p=0.003) and the presence of a primary renal tumor (p=0.001) were identified as independent poor prognostic factors by multivariate analysis. This study provides further evidence that changes in blood lymphocyte counts may serve as an objective indicator of objective responses.

Analysis of Changes in the Total Lymphocyte and Eosinophil Count during Immunotherapy for Metastatic Renal Cell Carcinoma: Correlation with Response and Survival. Publishing Authors By Initials

IG Jeong,KS Han,JY Joung,WS Choi,SS Hwang,SO Yang,HK Seo,J Chung,KH Lee,IG Jeong,KS Han,JY Joung,WS Choi,SS Hwang,SO Yang,HK Seo,J Chung,KH Lee,IG Jeong,KS Han,JY Joung,WS Choi,SS Hwang,SO Yang,HK Seo,J Chung,KH Lee,IG Jeong,KS Han,JY Joung,WS Choi,SS Hwang,SO Yang,HK Seo,J Chung,KH Lee,

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Analysis of Changes in the Total Lymphocyte and Eosinophil Count during Immunotherapy for Metastatic Renal Cell Carcinoma: Correlation with Response and Survival. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Korean medical science

VOLUME: 22 Suppl

Page Numbers: S122-8

Journal Abbreviation: J. Korean Med. Sci.

ISSN: 1011-8934

DAY: 9

MONTH: Sep

YEAR: 2007

Analysis of Changes in the Total Lymphocyte and Eosinophil Count during Immunotherapy for Metastatic Renal Cell Carcinoma: Correlation with Response and Survival. Information

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LANGUAGE: eng

NlmUniqueID: 8703518

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AFFILIATION: Urologic Oncology Clinic, National Cancer Center, Goyang, Korea.

Country: Korea (South)

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MEDLINETA: J Korean Med Sci

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