Analysis of c-kit protein expression in pancreatic neoplasms and its implication for prognosis.

Analysis of c-kit protein expression in pancreatic neoplasms and its implication for prognosis. Research Abstract Details 

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Analysis of c-kit protein expression in pancreatic neoplasms and its implication for prognosis. Abstract Text:

Wataru Kimura,Jinfeng Ma,Akiko Takeshita,Takashi Yamamoto,Toshiyuki Moriya,Ichiro Hirai,Akira Fuse,

BACKGROUND/AIMS: To evaluate the expression and role of c-kit protein in the neoplasia of pancreatic neoplasms and its relationship to prognosis in invasive ductal carcinoma (IDC) of the pancreas. METHODOLOGY: The immunohistochemical expression of c-kit protein was studied in normal pancreatic tissues, intraductal papillary-mucinous neoplasms of the pancreas (IPMN), mucinous cystic neoplasm of the pancreas (MCN), and IDC of the pancreas. The immunoreactive score (IRS) of c-kit protein expression was examined in normal pancreatic ductal cells, neoplastic cells, and pancreatic endocrine cells. RESULTS: The IRS values of c-kit protein expression in various neoplastic cells were significantly higher than those in normal ductal cells. No significant difference was seen between IRS values of c-kit protein expression in various pancreatic neoplastic cells of IDC of the pancreas, IPMN and MCN. No significant difference was seen between IRS values of c-kit expression in endocrine cells among various pancreatic tissues. Furthermore, a survival analysis in patients with IDC of the pancreas showed an obvious trend toward decreased survival in patients with c-kit-positive cancer, and c-kit protein expression did not correlate with any clinicopathological factors in IDC of the pancreas. CONCLUSIONS: c-kit protein expression may play an important role in neoplasia of pancreatic neoplasms. In view of the result that c-kit protein expression was found in 8% of IDC of the pancreas, a clinical trial for STI-571 (Glivec) against pancreatic cancer may be warranted for selected pancreatic cancer patients with c-kit protein expression.

Analysis of c-kit protein expression in pancreatic neoplasms and its implication for prognosis. Publishing Authors By Initials

W Kimura,J Ma,A Takeshita,T Yamamoto,T Moriya,I Hirai,A Fuse,

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Analysis of c-kit protein expression in pancreatic neoplasms and its implication for prognosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepato-gastroenterology

VOLUME: 54

Page Numbers: 2203-8

Journal Abbreviation: Hepatogastroenterology

ISSN: 0172-6390

DAY: 12

MONTH: Dec

YEAR: 2007

Analysis of c-kit protein expression in pancreatic neoplasms and its implication for prognosis. Information

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LANGUAGE: eng

NlmUniqueID: 8007849

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Grant and Affiliation Information for Analysis of c-kit protein expression in pancreatic neoplasms and its implication for prognosis.

AFFILIATION: Department of Gastroenterological and General Surgery, Graduate School of Medicine, Yamagata, Japan. wkimura@med.id.yamagata-u.ac.jp

Country: Greece

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MEDLINETA: Hepatogastroenterology

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