Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample.

Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Research Abstract Details 

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Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Abstract Text:

Jeffrey B Kraft,Eric J Peters,Susan L Slager,Greg D Jenkins,Megan S Reinalda,Patrick J McGrath,Steven P Hamilton,

BACKGROUND: SLC6A4 encodes the serotonin transporter, the protein primarily responsible for the termination of serotonin neurotransmission. Because many antidepressants inhibit the transporter, it has been the focus of intense pharmacogenetic analysis. We sought to replicate our previous findings that SLC6A4 is associated with response to a selective serotonin reuptake inhibitor (SSRI) in a large case-control study. METHODS: Genotypes at the SLC6A4 locus were obtained for 1,914 subjects in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and then tested for association to treatment response of the SSRI citalopram. RESULTS: Nine tagging single nucleotide polymorphisms and two variants previously associated with antidepressant response, including a promoter repeat polymorphism, were genotyped. Single marker and haplotypic analyses failed to detect association with antidepressant response in the largest clinical sample studied to date. CONCLUSIONS: The lack of association between response to an SSRI and variation at the SLC6A4 locus in this large sample, carefully characterized for response to citalopram, strongly suggests that SSRI response in major depression is not determined by DNA variation at this locus. These findings do not replicate findings of a number of studies with considerably smaller sample sizes. Other genetic determinants of SSRI response in depression should be sought.

Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Publishing Authors By Initials

JB Kraft,EJ Peters,SL Slager,GD Jenkins,MS Reinalda,PJ McGrath,SP Hamilton,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 61

Page Numbers: 734-42

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 21

MONTH: 11

YEAR: 2006

Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 213264

Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Information

Substance Name: Citalopram

Registry Number: 59729-33-8

Grant and Affiliation Information for Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample.

AFFILIATION: Department of Psychiatry and Center for Human Genetics, University of California, San Francisco, California 94143-0984, USA.

Country: United States

AGENCY: United States NIMH

GRANT: N01MH90003

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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