Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography.

Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. Research Abstract Details 

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Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. Abstract Text:

Bassam M Tashtoush,Jaber Qasem,Joshua D Williams,Tad P DeWald,Elaine L Jacobson,Myron K Jacobson,

Myristyl nicotinate is an ester prodrug under development for delivery of nicotinic acid to skin for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids. The formulation stability of myristyl nicotinate is crucial because even small amounts of free nicotinic acid cause skin flushing, an effect that is not harmful but would severely limit tolerability. We report here reversed-phase HPLC methods for the rapid analysis of myristyl nicotinate and nicotinic acid in dermatological preparations. Because of the large differences in polarity, myristyl nicotinate and nicotinic acid were analyzed by different chromatographic conditions, but they can be rapidly extracted from cream formulations using HPLC mobile phase as a solvent followed by HPLC analysis in less than 10 min. The methods were validated in terms of linearity, precision and accuracy and mean recovery of myristyl nicotinate from topical creams ranged from 97.0-101.2%. Nicotinic acid at levels of 0.01% in the formulations could be quantified. Stability studies show that myristyl nicotinate formulations are stable at room temperature for 3 years with less than 0.05% conversion to nicotinic acid. These methods will be effective for routine analysis of myristyl nicotinate stability in dermatological formulations.

Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. Publishing Authors By Initials

BM Tashtoush,J Qasem,JD Williams,TP DeWald,EL Jacobson,MK Jacobson,

For similar investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, ultraviolet research abstracts see: investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, ultraviolet research

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Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 43

Page Numbers: 893-9

Journal Abbreviation:

ISSN: 0731-7085

DAY: 16

MONTH: 10

YEAR: 2006

Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309336

Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. Keywords Mesh Terms:

KEYWORDS: Spectrophotometry, Ultraviolet

MESH TERMS: analysis

Chemical & Substance for Abstract: Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. Information

Substance Name: Niacin

Registry Number: 59-67-6

Grant and Affiliation Information for Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography.

AFFILIATION: Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Country: England

AGENCY: United States NCI

GRANT: R44 CA-90084

ACRONYM: CA

MEDLINETA: J Pharm Biomed Anal

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