An Unusually Low Microsatellite Mutation Rate in Dictyostelium discoideum, an Organism With Unusually Abundant Microsatellites.

An Unusually Low Microsatellite Mutation Rate in Dictyostelium discoideum, an Organism With Unusually Abundant Microsatellites. Research Abstract Details 

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An Unusually Low Microsatellite Mutation Rate in Dictyostelium discoideum, an Organism With Unusually Abundant Microsatellites. Abstract Text:

Ryan McConnell,Sara Middlemist,Clea Scala,Joan E Strassmann,David C Queller,Ryan McConnell,Sara Middlemist,Clea Scala,Joan E Strassmann,David C Queller,Ryan McConnell,Sara Middlemist,Clea Scala,Joan E Strassmann,David C Queller,

The genome of the social amoeba Dictyostelium discoideum is known to have a very high density of microsatellite repeats, including thousands of triplet microsatellite repeats in coding regions that apparently code for long runs of single amino acids. We used a mutation accumulation study to see if unusually high microsatellite mutation rates contribute to this pattern. There was a modest bias toward mutations that increase repeat number, but because upward mutations were smaller than downward ones, this did not lead to a net average increase in size. Longer microsatellites had higher mutation rates than shorter ones, but did not show greater directional bias. The most striking finding is that the overall mutation rate is the lowest reported for microsatellites: approximately 1 x 10(-6) for 10 dinucleotide loci and 6 x 10(-6) for 52 trinucleotide loci (which were longer). High microsatellite mutation rates therefore do not explain the high incidence of microsatellites. The causal relation may in fact be reversed, with low mutation rates evolving to protect against deleterious fitness effects of mutation at the numerous microsatellites.

An Unusually Low Microsatellite Mutation Rate in Dictyostelium discoideum, an Organism With Unusually Abundant Microsatellites. Publishing Authors By Initials

R McConnell,S Middlemist,C Scala,JE Strassmann,DC Queller,R McConnell,S Middlemist,C Scala,JE Strassmann,DC Queller,R McConnell,S Middlemist,C Scala,JE Strassmann,DC Queller,

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An Unusually Low Microsatellite Mutation Rate in Dictyostelium discoideum, an Organism With Unusually Abundant Microsatellites. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genetics

VOLUME: 177

Page Numbers: 1499-507

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 18

MONTH: 10

YEAR: 2007

An Unusually Low Microsatellite Mutation Rate in Dictyostelium discoideum, an Organism With Unusually Abundant Microsatellites. Information

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LANGUAGE: eng

NlmUniqueID: 374636

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Grant and Affiliation Information for An Unusually Low Microsatellite Mutation Rate in Dictyostelium discoideum, an Organism With Unusually Abundant Microsatellites.

AFFILIATION: Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas 77005.

Country: United States

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MEDLINETA: Genetics

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