An unprecedented twist to ODCase catalytic activity.

An unprecedented twist to ODCase catalytic activity. Research Abstract Details 

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An unprecedented twist to ODCase catalytic activity. Abstract Text:

Masahiro Fujihashi,Angelica M Bello,Ewa Poduch,Lianhu Wei,Subhash C Annedi,Emil F Pai,Lakshmi P Kotra,

Orotidine-5'-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position of orotidine-5'-monophosphate. We reveal an unusual biochemical pathway of conversion of 6-cyano-uridine-5'-monophosphate by ODCase to barbiturate-5'-monophosphate via perhaps an electrophilic center at the C6 position, leading to inhibition. This potential of ODCase is very useful in the design of novel inhibitors.

An unprecedented twist to ODCase catalytic activity. Publishing Authors By Initials

M Fujihashi,AM Bello,E Poduch,L Wei,SC Annedi,EF Pai,LP Kotra,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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An unprecedented twist to ODCase catalytic activity. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 15048-50

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 2

MONTH: Nov

YEAR: 2005

An unprecedented twist to ODCase catalytic activity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

An unprecedented twist to ODCase catalytic activity. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: An unprecedented twist to ODCase catalytic activity. Information

Substance Name: Ornithine Decarboxylase

Registry Number: EC 4.1.1.17

Grant and Affiliation Information for An unprecedented twist to ODCase catalytic activity.

AFFILIATION: Molecular Design and Information Technology Center, Leslie Dan Faculty of Pharmacy, Toronto, ON M5S 2S2 Canada.

Country: United States

AGENCY: United States NCRR

GRANT: RR07707

ACRONYM: RR

MEDLINETA: J Am Chem Soc

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