An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia.

An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia. Research Abstract Details 

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An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia. Abstract Text:

N Matsumoto,T Ishihara,H Adachi,M Takahashi,S Miwa,

Electron microscopic observations on the process of red cell destruction in the spleen and liver of a patient with congenital Heinz body hemolytic anemia, associated with a new variant of unstable hemoglobin, are reported. Two major mechanisms of destruction of Heinz body-containing red cells were noted. One was phagocytosis of these cells in toto by cordal macrophages. The other mechanism though less significant quantitatively, was intravascular hemolysis of injured red cells in the splenic microvasculature. In the liver, phagocytosis of damaged red cells by Kupffer cells was rate and there was no evidence of intravascular hemolysis in this organ. These morphological findings, together with almost complete recovery from hemolysis following splenectomy, indicated that Heinz body-containing red cells were removed from the circulation predominantly by the spleen. In contrast to experimental Heinz body anemia in animals, Heinz bodies were present even in the nucleated cells.

An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia. Publishing Authors By Initials

N Matsumoto,T Ishihara,H Adachi,M Takahashi,S Miwa,

For similar surgical procedures, operative: splenectomy research abstracts see: surgical procedures, operative: splenectomy research

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An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv. A, Pathological anatomy and histo

VOLUME: 374

Page Numbers: 339-51

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ISSN: 0340-1227

DAY: 11

MONTH: Jul

YEAR: 1977

An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia. Information

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LANGUAGE: eng

NlmUniqueID: 7505137

An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia. Keywords Mesh Terms:

KEYWORDS: Splenectomy

MESH TERMS: pathology

Chemical & Substance for Abstract: An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia. Information

Substance Name: Hemoglobins, Abnormal

Registry Number: 0

Grant and Affiliation Information for An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia.

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Country: GERMANY, WEST

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MEDLINETA: Virchows Arch A Pathol Anat Hi

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