An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea.

An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea. Research Abstract Details 

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An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea. Abstract Text:

E Wilander,

An ultrastructural study of the early effects of intraperitoneal injection of 50 mg/kg body weight of N-nitrosomethylurea on the pancreatic islet tissue in Chinese hamsters was performed. Thirty minutes after injection there was slight dilatation of the endoplasmic reticulum and mitochondrial swelling in a few peripheral alpha2-cells near to capillaries and also in some beta-cells. After 1 hour these changes were more pronounced. After 3 hours, distinct nuclear pyknosis was seen in endocrine islet cells of all types together with beta-cells granular irregularities, disruption of granular cores and autophagy of alpha2-cell granules. During the following hours, marked derangement of intracellular structures, ending in obvious cellular destruction, was observed. The results indicate that N-nitrosomethylurea has a direct cytotoxic effect on the beta-, alpha2- and alpha1-cells of the islet tissue. The similarity between the ultrastructure of the pancreatic islets after injection of N-nitrosomethylurea and streptozotocin is discussed.

An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea. Publishing Authors By Initials

E Wilander,

For similar organic chemicals: nitroso compounds: nitrosourea compounds research abstracts see: organic chemicals: nitroso compounds: nitrosourea compounds research

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An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 83

Page Numbers: 213-21

Journal Abbreviation:

ISSN: 0365-4184

DAY: 20

MONTH: Mar

YEAR: 1975

An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea. Information

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LANGUAGE: eng

NlmUniqueID: 7508468

An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea. Keywords Mesh Terms:

KEYWORDS: Nitrosourea Compounds

MESH TERMS: pharmacology

Chemical & Substance for Abstract: An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea. Information

Substance Name: Methylnitrosourea

Registry Number: 684-93-5

Grant and Affiliation Information for An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Scand [A

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