An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis.

An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Research Abstract Details 

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An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Abstract Text:

Sebastian Klinge,Judy Hirst,Joseph D Maman,Torsten Krude,Luca Pellegrini,Sebastian Klinge,Judy Hirst,Joseph D Maman,Torsten Krude,Luca Pellegrini,

Primases synthesize the RNA primers that are necessary for replication of the parental DNA strands. Here we report that the heterodimeric archaeal/eukaryotic primase is an iron-sulfur (Fe-S) protein. Binding of the Fe-S cluster is mediated by an evolutionarily conserved domain at the C terminus of the large subunit. We further show that the Fe-S domain is essential to the unique ability of the eukaryotic primase to start DNA replication.

An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Publishing Authors By Initials

S Klinge,J Hirst,JD Maman,T Krude,L Pellegrini,S Klinge,J Hirst,JD Maman,T Krude,L Pellegrini,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

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An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature structural & molecular biology

VOLUME: 14

Page Numbers: 875-7

Journal Abbreviation: Nat. Struct. Mol. Biol.

ISSN: 1545-9993

DAY: 19

MONTH: 08

YEAR: 2007

An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101186374

An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: metabolism

Chemical & Substance for Abstract: An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Information

Substance Name: DNA Primase

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis.

AFFILIATION: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.

Country: United States

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Nat Struct Mol Biol

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