An interstitial network of podoplanin-expressing cells in the human endolymphatic duct.

An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Research Abstract Details 

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An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Abstract Text:

The human endolymphatic duct (ED) with encompassing interstitial connective tissue (CT) is believed to be important for endolymph resorption and fluid pressure regulation of the inner ear. The periductal CT cells are interconnected via numerous cellular extensions, but do not form vessel structures. Here we report that the periductal CT is populated by two distinct cell phenotypes; one expressing podoplanin, a protein otherwise found on lymph endothelia and on epithelia involved in fluid fluxes, and a second expressing a fibroblast marker. A majority of the interstitial cells expressed podoplanin but not the lymphatic endothelial cell markers hyaluronan receptor (LYVE-1) or vascular endothelial growth factor receptor-3 (VEGFR-3). The fibroblast marker positive cells were found close to the ED epithelium. In the mid- and distal parts of the ED, these cells were enriched under folded epithelia. Furthermore, subepithelial CT cells were found to express activated platelet derived growth factor (PDGF)-beta receptors. Cultured CT cells from human inner ear periductal and perisaccular explant tissues were identified as fibroblasts. These cells compacted a three-dimensional collagen lattice by a process that could be promoted by PDGF-BB, a factor involved in interstitial fluid pressure regulation. Our results are compatible with the notion that the periductal CT cells are involved in the regulation of inner ear fluid pressure. By active compaction of the periductal CT and by the formation of villous structures, the CT cells could modulate fluid fluxes over the ED epithelium as well as the longitudinal flow of endolymph in the ED.

An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Publishing Authors By Initials

For similar digestive, oral, and skin physiology: skin physiology research abstracts see: digestive, oral, and skin physiology: skin physiology research

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An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the Association for Research in Otolary

VOLUME: 7

Page Numbers: 38-47

Journal Abbreviation: J. Assoc. Res. Otolaryngol.

ISSN: 1525-3961

DAY: 12

MONTH: 01

YEAR: 2006

An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Information

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LANGUAGE: eng

NlmUniqueID: 100892857

An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Keywords Mesh Terms:

KEYWORDS: Skin Physiology

MESH TERMS: surgery

Chemical & Substance for Abstract: An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Information

Substance Name: PDPN protein, human

Registry Number: 0

Grant and Affiliation Information for An interstitial network of podoplanin-expressing cells in the human endolymphatic duct.

AFFILIATION: Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-751 23, Uppsala, Sweden. anna-karin.ekwall@imbim.uu.se

Country: United States

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MEDLINETA: J Assoc Res Otolaryngol

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